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Pregnane X receptor

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Line 21: Line 21:
**[[4j5w]] – hPXR LBD + hRXR LBD<br />
**[[4j5w]] – hPXR LBD + hRXR LBD<br />
-
*Pregnane X receptor complex with ligand
+
*Pregnane X receptor complex
**[[1ilh]], [[2qnv]] – hPXR LBD + ligand<br />
**[[1ilh]], [[2qnv]] – hPXR LBD + ligand<br />
Line 27: Line 27:
**[[1skx]] – hPXR LBD + antibiotic<br />
**[[1skx]] – hPXR LBD + antibiotic<br />
**[[3r8d]] – hPXR LBD + anti-HIV drug<br />
**[[3r8d]] – hPXR LBD + anti-HIV drug<br />
-
**[[1nrl]], [[2o9i]], [[5a86]] – hPXR LBD + nuclear receptor coactivator peptide + ligand<br />
+
**[[1nrl]], [[2o9i]], [[5a86]], [[5x0r]] – hPXR LBD + nuclear receptor coactivator peptide + ligand<br />
**[[4j5x]] – hPXR LBD + hRXR LBD + ligand<br />
**[[4j5x]] – hPXR LBD + hRXR LBD + ligand<br />
**[[3hvl]] – hPXR/steroid receptor coactivator + ligand<br />
**[[3hvl]] – hPXR/steroid receptor coactivator + ligand<br />
Line 35: Line 35:
**[[4x1f]], [[4x1g]] – hPXR LBD + estrogen derivative<br />
**[[4x1f]], [[4x1g]] – hPXR LBD + estrogen derivative<br />
**[[4xao]] – hPXR LBD + pesticide<br />
**[[4xao]] – hPXR LBD + pesticide<br />
-
 
+
**[[6s41]], [[6dup]] – hPXR LBD + inhibitor<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:25, 27 November 2019

Structure of human pregnane X receptor LBD complex with antibiotic rifampicin (PDB entry 1skx)

Drag the structure with the mouse to rotate

3D structures of pregnane X receptor

Updated on 27-November-2019

References

  1. ↑ Kliewer SA, Goodwin B, Willson TM. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev. 2002 Oct;23(5):687-702. PMID:12372848 doi:http://dx.doi.org/10.1210/er.2001-0038
  2. ↑ Koutsounas I, Theocharis S, Patsouris E, Giaginis C. Pregnane X receptor (PXR) at the crossroads of human metabolism and disease. Curr Drug Metab. 2013 Mar;14(3):341-50. PMID:23237007
  3. ↑ Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR. Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Mol Endocrinol. 2005 May;19(5):1125-34. Epub 2005 Feb 10. PMID:15705662 doi:10.1210/me.2004-0346

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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