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6ucv

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Revision as of 09:31, 27 November 2019

Cryo-EM structure of the mitochondrial TOM complex from yeast (tetramer)

Structural highlights

6ucv is a 20 chain structure with sequence from Baker's yeast. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	TOM40, ISP42, MOM38, YMR203W, YM8325.04 (Baker's yeast), TOM22, MAS17, MAS22, MOM22, YNL131W, N1217, N1862 (Baker's yeast), TOM5, MOM8A, YPR133W-A (Baker's yeast), TOM6, ISP6, YOR045W (Baker's yeast), TOM7, MOM7, YNL070W, N2378 (Baker's yeast)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TOM6_YEAST] Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM6 is involved in assembly and stability of the TOM complex.^[1] [TOM40_YEAST] Channel-forming protein essential for import of protein precursors into mitochondria.^[2] [TOM5_YEAST] Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM5 is involved in insertion of preproteins into the TOM40 translocation pore.^[3] [TOM22_YEAST] Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM70 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Docks TOM20 and TOM70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating.^[4] ^[5] ^[6] [TOM7_YEAST] Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM7 is involved in assembly and stability of the TOM complex.^[7]

References

↑ Model K, Meisinger C, Prinz T, Wiedemann N, Truscott KN, Pfanner N, Ryan MT. Multistep assembly of the protein import channel of the mitochondrial outer membrane. Nat Struct Biol. 2001 Apr;8(4):361-70. doi: 10.1038/86253. PMID:11276259 doi:http://dx.doi.org/10.1038/86253
↑ Rapaport D, Neupert W. Biogenesis of Tom40, core component of the TOM complex of mitochondria. J Cell Biol. 1999 Jul 26;146(2):321-31. doi: 10.1083/jcb.146.2.321. PMID:10427088 doi:http://dx.doi.org/10.1083/jcb.146.2.321
↑ Dietmeier K, Honlinger A, Bomer U, Dekker PJ, Eckerskorn C, Lottspeich F, Kubrich M, Pfanner N. Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Nature. 1997 Jul 10;388(6638):195-200. doi: 10.1038/40663. PMID:9217162 doi:http://dx.doi.org/10.1038/40663
↑ van Wilpe S, Ryan MT, Hill K, Maarse AC, Meisinger C, Brix J, Dekker PJ, Moczko M, Wagner R, Meijer M, Guiard B, Honlinger A, Pfanner N. Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase. Nature. 1999 Sep 30;401(6752):485-9. PMID:10519552 doi:http://dx.doi.org/10.1038/46802
↑ Model K, Meisinger C, Prinz T, Wiedemann N, Truscott KN, Pfanner N, Ryan MT. Multistep assembly of the protein import channel of the mitochondrial outer membrane. Nat Struct Biol. 2001 Apr;8(4):361-70. doi: 10.1038/86253. PMID:11276259 doi:http://dx.doi.org/10.1038/86253
↑ Honlinger A, Kubrich M, Moczko M, Gartner F, Mallet L, Bussereau F, Eckerskorn C, Lottspeich F, Dietmeier K, Jacquet M, et al.. The mitochondrial receptor complex: Mom22 is essential for cell viability and directly interacts with preproteins. Mol Cell Biol. 1995 Jun;15(6):3382-9. PMID:7760834
↑ Model K, Meisinger C, Prinz T, Wiedemann N, Truscott KN, Pfanner N, Ryan MT. Multistep assembly of the protein import channel of the mitochondrial outer membrane. Nat Struct Biol. 2001 Apr;8(4):361-70. doi: 10.1038/86253. PMID:11276259 doi:http://dx.doi.org/10.1038/86253

1 Structural highlights
2 Function
3 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6ucv"

@@ Line 3: / Line 3: @@
 <StructureSection load='6ucv' size='340' side='right'caption='[[6ucv]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6ucv]] is a 20 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UCV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UCV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6ucv]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UCV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UCV FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TOM40, ISP42, MOM38, YMR203W, YM8325.04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), TOM22, MAS17, MAS22, MOM22, YNL131W, N1217, N1862 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), TOM5, MOM8A, YPR133W-A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), TOM6, ISP6, YOR045W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), TOM7, MOM7, YNL070W, N2378 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ucv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ucv OCA], [http://pdbe.org/6ucv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ucv RCSB], [http://www.ebi.ac.uk/pdbsum/6ucv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ucv ProSAT]</span></td></tr>
 </table>
@@ Line 13: / Line 14: @@
 __TOC__
 </StructureSection>
+[[Category: Baker's yeast]]
 [[Category: Large Structures]]
 [[Category: Park, E]]

6ucv

From Proteopedia

Revision as of 09:31, 27 November 2019

Cryo-EM structure of the mitochondrial TOM complex from yeast (tetramer)

Structural highlights

Function

References

Contents

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