1a06

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1a06.jpg|left|200px]]
[[Image:1a06.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1a06 |SIZE=350|CAPTION= <scene name='initialview01'>1a06</scene>, resolution 2.5&Aring;
+
The line below this paragraph, containing "STRUCTURE_1a06", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1a06| PDB=1a06 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a06 OCA], [http://www.ebi.ac.uk/pdbsum/1a06 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a06 RCSB]</span>
+
-
}}
+
'''CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT'''
'''CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT'''
Line 28: Line 25:
[[Category: Goldberg, J.]]
[[Category: Goldberg, J.]]
[[Category: Kuriyan, J.]]
[[Category: Kuriyan, J.]]
-
[[Category: calcium/calmodulin]]
+
[[Category: Calcium/calmodulin]]
-
[[Category: kinase]]
+
[[Category: Kinase]]
-
[[Category: signal transduction]]
+
[[Category: Signal transduction]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:36:39 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:30:18 2008''
+

Revision as of 06:36, 2 May 2008

Image:1a06.jpg

Template:STRUCTURE 1a06

CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT


Overview

The crystal structure of calcium/calmodulin-dependent protein kinase I has been determined in the autoinhibited form. The C-terminal regulatory region of the enzyme forms a helix-loop-helix segment that extends across the two domains of the catalytic core, making multiple inhibitory interactions. Elements of the first regulatory alpha helix and the loop interfere with the binding site for peptide substrates, while the loop and the second helix interact with the ATP-binding domain to induce conformational changes that obstruct the nucleotide binding pocket. One part of the calmodulin recognition element protrudes away from the catalytic domain and is potentially available for an initial interaction with calmodulin. The structure provides a view of an intact calmodulin target and suggests that substantial structural changes will accompany kinase activation by calmodulin binding to the regulatory region.

About this Structure

1A06 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I., Goldberg J, Nairn AC, Kuriyan J, Cell. 1996 Mar 22;84(6):875-87. PMID:8601311 Page seeded by OCA on Fri May 2 09:36:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a06"
Personal tools