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6c48

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==Crystal structure of B-Myb-LIN9-LIN52 complex==
==Crystal structure of B-Myb-LIN9-LIN52 complex==
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<StructureSection load='6c48' size='340' side='right' caption='[[6c48]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
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<StructureSection load='6c48' size='340' side='right'caption='[[6c48]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6c48]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C48 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6c48]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C48 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LIN9, BARA, TGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), MYBL2, BMYB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LIN52, C14orf46 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c48 OCA], [http://pdbe.org/6c48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c48 RCSB], [http://www.ebi.ac.uk/pdbsum/6c48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c48 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c48 OCA], [http://pdbe.org/6c48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c48 RCSB], [http://www.ebi.ac.uk/pdbsum/6c48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c48 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LIN9_HUMAN LIN9_HUMAN]] Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.<ref>PMID:15538385</ref> <ref>PMID:16730350</ref> [[http://www.uniprot.org/uniprot/MYBB_HUMAN MYBB_HUMAN]] Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.<ref>PMID:10770937</ref>
[[http://www.uniprot.org/uniprot/LIN9_HUMAN LIN9_HUMAN]] Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.<ref>PMID:15538385</ref> <ref>PMID:16730350</ref> [[http://www.uniprot.org/uniprot/MYBB_HUMAN MYBB_HUMAN]] Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.<ref>PMID:10770937</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The MuvB transcriptional regulatory complex, which controls cell-cycle-dependent gene expression, cooperates with B-Myb to activate genes required for the G2 and M phases of the cell cycle. We have identified the domain in B-Myb that is essential for the assembly of the Myb-MuvB (MMB) complex. We determined a crystal structure that reveals how this B-Myb domain binds MuvB through the adaptor protein LIN52 and the scaffold protein LIN9. The structure and biochemical analysis provide an understanding of how oncogenic B-Myb is recruited to regulate genes required for cell-cycle progression, and the MMB interface presents a potential therapeutic target to inhibit cancer cell proliferation.
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Structural mechanism of Myb-MuvB assembly.,Guiley KZ, Iness AN, Saini S, Tripathi S, Lipsick JS, Litovchick L, Rubin SM Proc Natl Acad Sci U S A. 2018 Sep 17. pii: 1808136115. doi:, 10.1073/pnas.1808136115. PMID:30224471<ref>PMID:30224471</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6c48" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Guiley, K Z]]
[[Category: Guiley, K Z]]
[[Category: Rubin, S M]]
[[Category: Rubin, S M]]

Current revision

Crystal structure of B-Myb-LIN9-LIN52 complex

PDB ID 6c48

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