1a1t

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[[Image:1a1t.gif|left|200px]]
[[Image:1a1t.gif|left|200px]]
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{{Structure
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|PDB= 1a1t |SIZE=350|CAPTION= <scene name='initialview01'>1a1t</scene>
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The line below this paragraph, containing "STRUCTURE_1a1t", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= NC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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|DOMAIN=
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{{STRUCTURE_1a1t| PDB=1a1t | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a1t OCA], [http://www.ebi.ac.uk/pdbsum/1a1t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a1t RCSB]</span>
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'''STRUCTURE OF THE HIV-1 NUCLEOCAPSID PROTEIN BOUND TO THE SL3 PSI-RNA RECOGNITION ELEMENT, NMR, 25 STRUCTURES'''
'''STRUCTURE OF THE HIV-1 NUCLEOCAPSID PROTEIN BOUND TO THE SL3 PSI-RNA RECOGNITION ELEMENT, NMR, 25 STRUCTURES'''
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[[Category: Summers, M F.]]
[[Category: Summers, M F.]]
[[Category: Wu, Z R.]]
[[Category: Wu, Z R.]]
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[[Category: complex (nucleocapsid protein/rna)]]
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[[Category: Nucleocapsid protein]]
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[[Category: nucleocapsid protein]]
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[[Category: Stem-loop rna]]
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[[Category: stem-loop rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:40:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:31:20 2008''
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Revision as of 06:40, 2 May 2008

Image:1a1t.gif

Template:STRUCTURE 1a1t

STRUCTURE OF THE HIV-1 NUCLEOCAPSID PROTEIN BOUND TO THE SL3 PSI-RNA RECOGNITION ELEMENT, NMR, 25 STRUCTURES


Overview

The three-dimensional structure of the human immunodeficiency virus-type 1 (HIV-1) nucleocapsid protein (NC) bound to the SL3 stem-loop recognition element of the genomic Psi RNA packaging signal has been determined by heteronuclear magnetic resonance spectroscopy. Tight binding (dissociation constant, approximately 100 nM) is mediated by specific interactions between the amino- and carboxyl-terminal CCHC-type zinc knuckles of the NC protein and the G7 and G9 nucleotide bases, respectively, of the G6-G7-A8-G9 RNA tetraloop. A8 packs against the amino-terminal knuckle and forms a hydrogen bond with conserved Arg32, and residues Lys3 to Arg10 of NC form a 310 helix that binds to the major groove of the RNA stem and also packs against the amino-terminal zinc knuckle. The structure provides insights into the mechanism of viral genome recognition, explains extensive amino acid conservation within NC, and serves as a basis for the development of inhibitors designed to interfere with genome encapsidation.

About this Structure

1A1T is a Single protein structure of sequence from Human immunodeficiency virus 1. The following page contains interesting information on the relation of 1A1T with [Zinc Fingers]. Full crystallographic information is available from OCA.

Reference

Structure of the HIV-1 nucleocapsid protein bound to the SL3 psi-RNA recognition element., De Guzman RN, Wu ZR, Stalling CC, Pappalardo L, Borer PN, Summers MF, Science. 1998 Jan 16;279(5349):384-8. PMID:9430589 Page seeded by OCA on Fri May 2 09:40:49 2008

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OCA

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