1a35

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1a35.jpg|left|200px]]
[[Image:1a35.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1a35 |SIZE=350|CAPTION= <scene name='initialview01'>1a35</scene>, resolution 2.500&Aring;
+
The line below this paragraph, containing "STRUCTURE_1a35", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BRU:5-BROMO-2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase DNA topoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.2 5.99.1.2] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1a35| PDB=1a35 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a35 OCA], [http://www.ebi.ac.uk/pdbsum/1a35 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a35 RCSB]</span>
+
-
}}
+
'''HUMAN TOPOISOMERASE I/DNA COMPLEX'''
'''HUMAN TOPOISOMERASE I/DNA COMPLEX'''
Line 31: Line 28:
[[Category: Redinbo, M R.]]
[[Category: Redinbo, M R.]]
[[Category: Stewart, L.]]
[[Category: Stewart, L.]]
-
[[Category: dna]]
+
[[Category: Dna]]
-
[[Category: topoisomerase i]]
+
[[Category: Topoisomerase i]]
-
[[Category: topoisomerase i/dna)]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:44:25 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:32:14 2008''
+

Revision as of 06:44, 2 May 2008

Image:1a35.jpg

Template:STRUCTURE 1a35

HUMAN TOPOISOMERASE I/DNA COMPLEX


Overview

Topoisomerases I promote the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination. The crystal structures at 2.1 and 2.5 angstrom resolution of reconstituted human topoisomerase I comprising the core and carboxyl-terminal domains in covalent and noncovalent complexes with 22-base pair DNA duplexes reveal an enzyme that "clamps" around essentially B-form DNA. The core domain and the first eight residues of the carboxyl-terminal domain of the enzyme, including the active-site nucleophile tyrosine-723, share significant structural similarity with the bacteriophage family of DNA integrases. A binding mode for the anticancer drug camptothecin is proposed on the basis of chemical and biochemical information combined with these three-dimensional structures of topoisomerase I-DNA complexes.

About this Structure

1A35 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA., Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WG, Science. 1998 Mar 6;279(5356):1504-13. PMID:9488644 Page seeded by OCA on Fri May 2 09:44:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a35"
Personal tools