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Rho GTPase

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*<scene name='75/752220/Cv/7'>GDP binding site</scene>
*<scene name='75/752220/Cv/7'>GDP binding site</scene>
*<scene name='75/752220/Cv/8'>AlF4 and Mg+2 ion binding site</scene>.
*<scene name='75/752220/Cv/8'>AlF4 and Mg+2 ion binding site</scene>.
 +
==3D structures of Rho GTPase==
 +
[[Rho GTPase 3D structures]]
</StructureSection>
</StructureSection>
Line 87: Line 89:
**[[1m7b]] – hRhoE + GTP <br />
**[[1m7b]] – hRhoE + GTP <br />
-
**[[1gwn]] – mRhoE core domain + GTP <br />
 
**[[2v55]] – hRhoE + ROCKI + GTP + ANP<br />
**[[2v55]] – hRhoE + ROCKI + GTP + ANP<br />
 +
**[[1gwn]] – mRhoE core domain + GTP <br />
-
*Miro1
+
*Miro1 or mitochondrial Rho GTPase 1
 +
**[[6d71]] – hMiro1 N-terminal + GTP <br />
**[[5kso]], [[5ksp]], [[5ksy]] – hMiro1 C-terminal + GDP <br />
**[[5kso]], [[5ksp]], [[5ksy]] – hMiro1 C-terminal + GDP <br />
-
**[[5ksz]] – hMiro1 EF hand and kinase domain + GMPPCP <br />
+
**[[5ksz]] – hMiro1 EF hand and kinase domain residues 177-592 - GMPPCP <br />
**[[5kty]], [[5ku1]] – hMiro1 EF hand and kinase domain + GDP <br />
**[[5kty]], [[5ku1]] – hMiro1 EF hand and kinase domain + GDP <br />
Line 105: Line 108:
**[[4c0l]] – DmMiro + GDP <br />
**[[4c0l]] – DmMiro + GDP <br />
 +
*Rho1
 +
 +
**[[5zvp]] – Rho1 + GDP – ''Aspergillus fumigatus''<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:56, 15 December 2019

Human RhoA (magenta) complex with RhoGAP (cyan), GDP, AlF4 and Mg+2 ion (green) (PDB code 1tx4)

Drag the structure with the mouse to rotate

3D structures of Rho GTPase

Updated on 15-December-2019

References

  1. ↑ Sepp KJ, Auld VJ. RhoA and Rac1 GTPases mediate the dynamic rearrangement of actin in peripheral glia. Development. 2003 May;130(9):1825-35. PMID:12642488
  2. ↑ Fransson A, Ruusala A, Aspenstrom P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J Biol Chem. 2003 Feb 21;278(8):6495-502. Epub 2002 Dec 12. PMID:12482879 doi:http://dx.doi.org/10.1074/jbc.M208609200
  3. ↑ Zhou J, Hayakawa Y, Wang TC, Bass AJ. RhoA mutations identified in diffuse gastric cancer. Cancer Cell. 2014 Jul 14;26(1):9-11. doi: 10.1016/j.ccr.2014.06.022. PMID:25026207 doi:http://dx.doi.org/10.1016/j.ccr.2014.06.022
  4. ↑ Jin L, Burnett AL. RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights. Clin Sci (Lond). 2006 Feb;110(2):153-65. PMID:16411892 doi:http://dx.doi.org/10.1042/CS20050255
  5. ↑ Rittinger K, Walker PA, Eccleston JF, Smerdon SJ, Gamblin SJ. Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue. Nature. 1997 Oct 16;389(6652):758-62. PMID:9338791 doi:10.1038/39651

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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