1a5e

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a5e OCA], [http://www.ebi.ac.uk/pdbsum/1a5e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a5e RCSB]</span>
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'''SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, 18 STRUCTURES'''
'''SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, 18 STRUCTURES'''
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[[Category: Tevelev, A.]]
[[Category: Tevelev, A.]]
[[Category: Tsai, M D.]]
[[Category: Tsai, M D.]]
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[[Category: ank repeat]]
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[[Category: Ank repeat]]
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[[Category: anti-oncogene]]
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[[Category: Anti-oncogene]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: repeat]]
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[[Category: Repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:50:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:33:36 2008''
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Revision as of 06:50, 2 May 2008

Image:1a5e.gif

Template:STRUCTURE 1a5e

SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, 18 STRUCTURES


Overview

The solution structure of the tumor suppressor p16INK4A has been determined by NMR, and important recognition regions of both cdk4 and p16INK4A have been identified. The tertiary structure of p16INK4A contains four helix-turn-helix motifs linked by three loops. Twelve tumorigenic mutants of p16INK4A have been constructed and analyzed for their structure and activity, and new mutants have been designed rationally. A fragment of 58 residues at the N terminus of cdk4 important for p16INK4A binding has been identified. The importance of this region was further verified by mutational analysis of cdk4. These results and docking experiments have been used to assess possible modes of binding between p16INK4A and cdk4.

About this Structure

1A5E is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4., Byeon IJ, Li J, Ericson K, Selby TL, Tevelev A, Kim HJ, O'Maille P, Tsai MD, Mol Cell. 1998 Feb;1(3):421-31. PMID:9660926 Page seeded by OCA on Fri May 2 09:50:20 2008

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