Ribosomal protein S7

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[[Image:RPS7.png|left|200px|thumb|Crystal Structure of Ribosomal protein S7 from [[2zm6]], chain G]]
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<StructureSection load='1rss' size='350' side='right' scene='' caption='Ribosomal protein S7 (PDB code [[1rss]])'>
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{{STRUCTURE_2zm6| PDB=2zm6 | SIZE=300| SCENE=Ribosomal_protein_S7/Cv/1 |right|CAPTION=Ribosomal protein S7 from [[2zm6]], chain G }}
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== Function ==
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[[Ribosomal protein S7]] (RPS7) is one of the 22 proteins which belong to the 30S <scene name='Ribosomal_protein_S7/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]] or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. It binds to 16S RRNA and is one of the proteins responsible for the initiation of the 30S particle assembly. It crosslinks with tRNA at the A- and P-sites<ref>PMID:7016341</ref>.
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[[Ribosomal protein S7]] (RPS7) is one of the 22 proteins which belong to the <scene name='Ribosomal_protein_S7/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]]. It binds to 16S RRNA and is one of the proteins responsible for the initiation of the 30S particle assembly. It crosslinks with tRNA at the A- and P-sites. The images at the left and at the right correspond to one representative RPS7, ''i.e.'' the crystal structure of Ribosomal protein S7 from ''Thermus thermophilus'' ([[2zm6]], chain G).
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{{TOC limit|limit=2}}
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<br />
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<br />
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<br />
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== Disease ==
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Mutations in mitochondrial RPS7 cause congenital sensorineural deafness and progressive hepatic and renal failure<ref>PMID:25556185</ref>.
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</StructureSection>
== 3D Structures of Ribosomal protein S7 ==
== 3D Structures of Ribosomal protein S7 ==
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===RPS7===
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1iqv]] – RPS7 – ''Pyrococcus horikoshii''<br />
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[[1rss]] – TtRPS7 - ''Thermus thermophilus''<br />
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[[1hus]] – RPS7 – ''Geobacillus stearothermophilus''
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===S7 in small ribosomal subunit===
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[[2zm6]], [[1n36]], [[1j5e]] - TtRPS5 in 30S ribosomal subunit+THX+16S RRNA – ''Thermus thermophilus''<br />
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[[2vqe]], [[2vqf]], [[2uuc]], [[2e5l]], [[2uu9]], [[2uua]], [[2uub]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+RNA fragment<br />
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[[3kc4]] – EcRPS5 in 30S ribosomal subunit - ''Escherichia coli''<br />
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[[3i1m]], [[3i1o]], [[3df1]], [[3df3]], [[2vho]], [[2vhp]], [[2avy]], [[2aw7]], [[1pnx]] - EcRPS5 in 30S ribosomal subunit+16S RRNA<br />
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[[1i94]], [[1fka]] - TtRPS5 in 30S ribosomal subunit+16S RRNA<br />
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[[1p87]], [[1p6g]] - EcRPS5 in 30S ribosomal subunit+16S RRNA – Cryo-EM<br />
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[[3bbn]] - RPS5 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach
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===S7 in small + large ribosomal subunit===
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[[1ml5]] - EcRPS5 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM
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===S7 in small ribosomal subunit+ chain release factor===
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[[3mr8]], [[3ms0]] – TtRPS5 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA <br />
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[[3d5a]], [[3d5c]] - TtRPS5 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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[[2b64]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1<br />
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[[2b9m]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2<br />
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[[2x9r]], [[2x9t]], [[2wh1]], [[2wh3]] - TtRPS5 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA<br />
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[[3f1e]], [[3f1g]] - TtRPS5 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA
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===S7 in small ribosomal subunit+tRNA+mRNA===
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[[2hgi]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet<br />
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[[2hgp]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
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[[2i2p]], [[2i2u]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
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[[2hgr]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA<br />
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[[1yl4]] – TtRPS5 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator<br />
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[[1pns]] - EcRPS5 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA <br />
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[[1xnq]], [[1xnr]] - TtRPS5 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA
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===S7 in small ribosomal subunit+A-site tRNA===
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[[2uxd]], [[2uxc]] - TtRPS5 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA<br />
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[[1n32]], [[1n33]] - TtRPS5 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA<br />
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[[1n34]] - TtRPS5 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA<br />
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[[1xmo]], [[1xmq]] - TtRPS5 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA<br />
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[[2uxb]] - TtRPS5 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA
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===S7 in small ribosomal subunit+P-site tRNA===
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[[3i8g]] - TtRPS5 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA<br />
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[[3i8h]], [[3i9b]], [[3i9d]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA<br />
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[[1ibk]] - TtRPS5 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA<br />
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[[2wwl]] - EcRPS5 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA - ''Escherichia coli''<br />
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[[3i1q]] - EcRPS5 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA<br />
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[[3i1s]], [[3i1z]], [[3i21]] - EcRPS5 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA
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===S7 in small ribosomal subunit+A-site tRNA+P-site tRNA===
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[[1ibl]], [[1ibm]] - TtRPS5 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA
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===S7 in small ribosomal subunit+P-site tRNA+E-site tRNA===
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[[2ow8]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA<br />
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[[2b9o]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA<br />
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[[2qnh]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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[[2wdg]], [[2wdh]], [[2wdk]], [[2wdm]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe
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===S7 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA===
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[[2gy9]], [[2gyb]] - EcRPS5 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM<br />
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[[1jgo]], [[1jgp]], [[1jgq]], [[1gix]] - TtRPS5 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA<br />
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[[3e1a]], [[3e1c]] - EcRPS5 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA
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===S7 in small ribosomal subunit + antibiotics===
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[[1i95]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+edeine<br />
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[[1i97]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+tetracycline<br />
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[[1hnw]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+mRNA fragment+tetracycline<br />
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[[1hnx]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+mRNA fragment+pactamycin <br />
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[[1hnz]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+mRNA fragment+hygromycin B<br />
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[[1fjg]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+mRNA fragment+streptomycin<br />
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[[2qbb]], [[2qb9]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+kasugamyin<br />
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[[2hhh]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+kasugamyin<br />
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[[2f4v]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+designed antibiotic<br />
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[[1vs5]], [[1vs7]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+gentamicin<br />
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[[2qan]], [[2qal]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+neomycin<br />
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[[2qou]], [[2qow]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+spectinomycin<br />
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[[2qoy]], [[2qp0]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+spectinomycin+neomycin<br />
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[[2z4k]], [[2z4m]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+paromomycin<br />
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[[2j00]], [[2j02]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA<br />
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[[3knj]], [[3knh]] - TtRPS5 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+viomycin<br />
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[[3knl]], [[3knm]] - TtRPS5 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+capreomycin
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===S7 in small ribosomal subunit + ribosome recycling factor===
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[[2qbd]], [[2qbf]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor<br />
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[[2qbh]], [[2qbj]] - EcRPS5 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin<br />
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[[2v46]], [[2v48]] - TtRPS5 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet
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===S7 in small ribosomal subunit + elongation factor===
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[[2wri]], [[2wrk]] - TtRPS5 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G<br />
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[[2wrn]], [[2wrq]] - TtRPS5 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4<br />
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[[3fic]] - TtRPS5 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A<br />
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[[3fih]] - EcRPS5 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU<br />
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[[3huw]], [[3huy]] - TtRPS5 in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P<br />
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===S7 in small ribosomal subunit + translation initiation factor===
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[[1i96]] - TtRPS5 in 30S ribosomal subunit+THX+IF3+16S RRNA<br />
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[[1hr0]] - TtRPS5 in 30S ribosomal subunit+THX+IF+16S RRNA
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===S7 in small ribosomal subunit + various proteins===
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[[3kiq]], [[3kis]], [[3kiu]], [[3kix]] - TtRPS5 in 30S ribosomal subunit+toxin RelE+16S RRNA<br />
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[[1voq]], [[1vos]], [[1vov]], [[1vox]], [[1voz]] - EcRPS5 in 30S ribosomal subunit+protein Y+16S RRNA<br />
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[[3gty]] – RPS7+trigger factor – ''Thermotoga maritima''<br />
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[[1x18]] – TtRPS7+TtRPS2+TtRPS11+TtRPS18+ERA GTPase+16S RRNA fragment
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*Ribosomal protein S7
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===S7 in part of small ribosomal subunit===
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**[[1iqv]] – RPS7 – ''Pyrococcus horikoshii''<br />
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**[[1rss]] – TtRPS7 - ''Thermus thermophilus''<br />
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**[[1hus]] – RPS7 – ''Geobacillus stearothermophilus''<br />
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**[[6jmk]] – RPS7 - ''Mycobacterium tuberculosis''<br />
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**[[3gty]] – RPS7 + trigger factor – ''Thermotoga maritima''<br />
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[[1qd7]] – TtRPS5+TtRPS4+TtRPS6+TtRPS7+TtRPS8+TtRPS15+TtRPS17+TtRPS20+16S RRNA fragment<br />
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*Ribosomal protein S7 in part of small ribosomal subunit
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[[1dv4]] – GsRPS5+TtRPS7+16S RRNA
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**[[1qd7]] – TtRPS7 + TtRPS4 +TtRPS6 +TtRPS5 +TtRPS8 +TtRPS15 +TtRPS17 +TtRPS20 +16S RRNA fragment<br />
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**[[1x18]] - TtRPS7+ TtRPS2 +TtRPS11 +TtRPS18 + RNA + GTP-binding protein – Cryo EM<br />
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**[[1dv4]] – GsRPS7+TtRPS5+16S RRNA
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein S7 (PDB code 1rss)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein S7

Updated on 24-December-2019

References

  1. ↑ Dean D, Yates JL, Nomura M. Identification of ribosomal protein S7 as a repressor of translation within the str operon of E. coli. Cell. 1981 May;24(2):413-9. PMID:7016341
  2. ↑ Menezes MJ, Guo Y, Zhang J, Riley LG, Cooper ST, Thorburn DR, Li J, Dong D, Li Z, Glessner J, Davis RL, Sue CM, Alexander SI, Arbuckle S, Kirwan P, Keating BJ, Xu X, Hakonarson H, Christodoulou J. Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia. Hum Mol Genet. 2015 Apr 15;24(8):2297-307. doi: 10.1093/hmg/ddu747. Epub 2015 Jan, 2. PMID:25556185 doi:http://dx.doi.org/10.1093/hmg/ddu747

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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