1a60
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1a60.gif|left|200px]] | [[Image:1a60.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1a60", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1a60| PDB=1a60 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''NMR STRUCTURE OF A CLASSICAL PSEUDOKNOT: INTERPLAY OF SINGLE-AND DOUBLE-STRANDED RNA, 24 STRUCTURES''' | '''NMR STRUCTURE OF A CLASSICAL PSEUDOKNOT: INTERPLAY OF SINGLE-AND DOUBLE-STRANDED RNA, 24 STRUCTURES''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A60 OCA]. | |
==Reference== | ==Reference== | ||
NMR structure of a classical pseudoknot: interplay of single- and double-stranded RNA., Kolk MH, van der Graaf M, Wijmenga SS, Pleij CW, Heus HA, Hilbers CW, Science. 1998 Apr 17;280(5362):434-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9545221 9545221] | NMR structure of a classical pseudoknot: interplay of single- and double-stranded RNA., Kolk MH, van der Graaf M, Wijmenga SS, Pleij CW, Heus HA, Hilbers CW, Science. 1998 Apr 17;280(5362):434-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9545221 9545221] | ||
| - | [[Category: Protein complex]] | ||
| - | [[Category: Turnip yellow mosaic virus]] | ||
[[Category: Graaf, M Van Der.]] | [[Category: Graaf, M Van Der.]] | ||
[[Category: Heus, H A.]] | [[Category: Heus, H A.]] | ||
| Line 31: | Line 26: | ||
[[Category: Pleij, C W.A.]] | [[Category: Pleij, C W.A.]] | ||
[[Category: Wijmenga, S S.]] | [[Category: Wijmenga, S S.]] | ||
| - | [[Category: | + | [[Category: Pseudoknot]] |
| - | [[Category: | + | [[Category: Ribonucleic acid]] |
| - | [[Category: | + | [[Category: Rna]] |
| - | [[Category: | + | [[Category: Tymv]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:51:49 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:51, 2 May 2008
NMR STRUCTURE OF A CLASSICAL PSEUDOKNOT: INTERPLAY OF SINGLE-AND DOUBLE-STRANDED RNA, 24 STRUCTURES
Overview
Pseudoknot formation folds the 3' ends of many plant viral genomic RNAs into structures that resemble transfer RNA in global folding and in their reactivity to transfer RNA-specific proteins. The solution structure of the pseudoknotted T arm and acceptor arm of the transfer RNA-like structure of turnip yellow mosaic virus (TYMV) was determined by nuclear magnetic resonance (NMR) spectroscopy. The molecule is stabilized by the hairpin formed by the 5' end of the RNA, and by the intricate interactions related to the loops of the pseudoknot. Loop 1 spans the major groove of the helix with only two of its four nucleotides. Loop 2, which crosses the minor groove, interacts closely with its opposing helix, in particular through hydrogen bonds with a highly conserved adenine. The structure resulting from this interaction between the minor groove and single-stranded RNA at helical junctions displays internal mobility, which may be a general feature of RNA pseudoknots that regulates their interaction with proteins or other RNA molecules.
About this Structure
Full crystallographic information is available from OCA.
Reference
NMR structure of a classical pseudoknot: interplay of single- and double-stranded RNA., Kolk MH, van der Graaf M, Wijmenga SS, Pleij CW, Heus HA, Hilbers CW, Science. 1998 Apr 17;280(5362):434-8. PMID:9545221 Page seeded by OCA on Fri May 2 09:51:49 2008
