6nha

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'''Unreleased structure'''
 
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The entry 6nha is ON HOLD until Paper Publication
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==Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody==
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<StructureSection load='6nha' size='340' side='right'caption='[[6nha]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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Authors: Blumberg, R.S., Cheung, J., Mahmood, A., Gandhi, A.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6nha]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NHA FirstGlance]. <br>
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Description: Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nha OCA], [http://pdbe.org/6nha PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nha RCSB], [http://www.ebi.ac.uk/pdbsum/6nha PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nha ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/FCGRN_HUMAN FCGRN_HUMAN]] Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Blumberg, R S]]
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[[Category: Cheung, J]]
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[[Category: Gandhi, A K]]
[[Category: Mahmood, A]]
[[Category: Mahmood, A]]
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[[Category: Cheung, J]]
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[[Category: B2m]]
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[[Category: Blumberg, R.S]]
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[[Category: Circulating igg and igg immune complex]]
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[[Category: Gandhi, A.K]]
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[[Category: Fcrn]]
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[[Category: Immune system]]
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[[Category: Synt001]]

Revision as of 09:08, 25 December 2019

Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody

PDB ID 6nha

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