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6uv5
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate== | |
| - | + | <StructureSection load='6uv5' size='340' side='right'caption='[[6uv5]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6uv5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UV5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ATP_citrate_synthase ATP citrate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.8 2.3.3.8] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uv5 OCA], [http://pdbe.org/6uv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uv5 RCSB], [http://www.ebi.ac.uk/pdbsum/6uv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uv5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN]] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: ATP citrate synthase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ronen, M]] | ||
[[Category: Xuepeng, W]] | [[Category: Xuepeng, W]] | ||
| - | [[Category: | + | [[Category: Lyase]] |
Revision as of 09:22, 25 December 2019
Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate
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