1a6e

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[[Image:1a6e.gif|left|200px]]
[[Image:1a6e.gif|left|200px]]
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{{Structure
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|PDB= 1a6e |SIZE=350|CAPTION= <scene name='initialview01'>1a6e</scene>, resolution 3.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1a6e", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ASB:Residue+Numbering+According+To+Alpha-Type+Subunit'>ASB</scene> and <scene name='pdbsite=ASE:Residue+Numbering+According+To+Alpha-Type+Subunit'>ASE</scene>
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1a6e| PDB=1a6e | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6e OCA], [http://www.ebi.ac.uk/pdbsum/1a6e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a6e RCSB]</span>
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}}
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'''THERMOSOME-MG-ADP-ALF3 COMPLEX'''
'''THERMOSOME-MG-ADP-ALF3 COMPLEX'''
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[[Category: Stetter, K O.]]
[[Category: Stetter, K O.]]
[[Category: Stock, D.]]
[[Category: Stock, D.]]
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[[Category: atp hydrolysis]]
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[[Category: Atp hydrolysis]]
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[[Category: atpase]]
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[[Category: Atpase]]
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[[Category: cct]]
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[[Category: Cct]]
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[[Category: group ii chaperonin]]
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[[Category: Group ii chaperonin]]
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[[Category: protein folding]]
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[[Category: Protein folding]]
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[[Category: thermoplasma acidophilum]]
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[[Category: Thermoplasma acidophilum]]
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[[Category: transition state complex]]
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[[Category: Transition state complex]]
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[[Category: tric]]
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[[Category: Tric]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:52:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:34:15 2008''
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Revision as of 06:52, 2 May 2008

Image:1a6e.gif

Template:STRUCTURE 1a6e

THERMOSOME-MG-ADP-ALF3 COMPLEX


Overview

We have determined to 2.6 A resolution the crystal structure of the thermosome, the archaeal group II chaperonin from T. acidophilum. The hexadecameric homolog of the eukaryotic chaperonin CCT/TRiC shows an (alphabeta)4(alphabeta)4 subunit assembly. Domain folds are homologous to GroEL but form a novel type of inter-ring contact. The domain arrangement resembles the GroEL-GroES cis-ring. Parts of the apical domains form a lid creating a closed conformation. The lid substitutes for a GroES-like cochaperonin that is absent in the CCT/TRiC system. The central cavity has a polar surface implicated in protein folding. Binding of the transition state analog Mg-ADP-AIF3 suggests that the closed conformation corresponds to the ATP form.

About this Structure

1A6E is a Protein complex structure of sequences from Thermoplasma acidophilum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT., Ditzel L, Lowe J, Stock D, Stetter KO, Huber H, Huber R, Steinbacher S, Cell. 1998 Apr 3;93(1):125-38. PMID:9546398 Page seeded by OCA on Fri May 2 09:52:55 2008

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OCA

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