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1a7s

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[[Image:1a7s.gif|left|200px]]
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{{Structure
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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{{STRUCTURE_1a7s| PDB=1a7s | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7s OCA], [http://www.ebi.ac.uk/pdbsum/1a7s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a7s RCSB]</span>
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'''ATOMIC RESOLUTION STRUCTURE OF HBP'''
'''ATOMIC RESOLUTION STRUCTURE OF HBP'''
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[[Category: Kastrup, J S.]]
[[Category: Kastrup, J S.]]
[[Category: Larsen, I K.]]
[[Category: Larsen, I K.]]
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[[Category: endotoxin binding]]
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[[Category: Endotoxin binding]]
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[[Category: heparin]]
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[[Category: Heparin]]
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[[Category: serine protease homolog]]
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[[Category: Serine protease homolog]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:56:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:35:04 2008''
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Revision as of 06:56, 2 May 2008

Image:1a7s.gif

Template:STRUCTURE 1a7s

ATOMIC RESOLUTION STRUCTURE OF HBP


Overview

Crystals of human heparin binding protein (HBP) diffract to 1.1 A when flash-frozen at 120 K. The atomic resolution structure has been refined anisotropically using SHELXL96. The final model of HBP consists of 221 amino-acid residues of 225 possible, three glycosylation units, one chloride ion, 15 precipitant ethanol molecules and 323 water molecules. The structure is refined to a final crystallographic R factor of 15.9% and Rfree(5%) of 18.9% using all data. A putative protein kinase C activation site has been identified, involving residues 113-120. The structure is compared to the previously determined 2.3 A resolution structure of HBP.

About this Structure

1A7S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Atomic resolution structure of human HBP/CAP37/azurocidin., Karlsen S, Iversen LF, Larsen IK, Flodgaard HJ, Kastrup JS, Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):598-609. PMID:9761855 Page seeded by OCA on Fri May 2 09:56:34 2008

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