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1a8b

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[[Image:1a8b.gif|left|200px]]
[[Image:1a8b.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1a8b |SIZE=350|CAPTION= <scene name='initialview01'>1a8b</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1a8b", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=GPE:Gpe+Binding+Site+(Includes+1+Ca+Ion)'>GPE</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GPE:L-ALPHA-GLYCEROPHOSPHORYLETHANOLAMINE'>GPE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1a8b| PDB=1a8b | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8b OCA], [http://www.ebi.ac.uk/pdbsum/1a8b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a8b RCSB]</span>
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}}
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'''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE'''
'''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE'''
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[[Category: Seaton, B A.]]
[[Category: Seaton, B A.]]
[[Category: Swairjo, M A.]]
[[Category: Swairjo, M A.]]
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[[Category: calcium binding protein]]
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[[Category: Calcium binding protein]]
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[[Category: membrane binding protein]]
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[[Category: Membrane binding protein]]
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[[Category: phospholipid analog]]
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[[Category: Phospholipid analog]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:57:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:35:23 2008''
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Revision as of 06:57, 2 May 2008

Image:1a8b.gif

Template:STRUCTURE 1a8b

RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE


Overview

Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.

About this Structure

1A8B is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670 Page seeded by OCA on Fri May 2 09:57:51 2008

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