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1a9n

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[[Image:1a9n.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9n OCA], [http://www.ebi.ac.uk/pdbsum/1a9n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a9n RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE SPLICEOSOMAL U2B''-U2A' PROTEIN COMPLEX BOUND TO A FRAGMENT OF U2 SMALL NUCLEAR RNA'''
'''CRYSTAL STRUCTURE OF THE SPLICEOSOMAL U2B''-U2A' PROTEIN COMPLEX BOUND TO A FRAGMENT OF U2 SMALL NUCLEAR RNA'''
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[[Category: Nagai, K.]]
[[Category: Nagai, K.]]
[[Category: Price, S R.]]
[[Category: Price, S R.]]
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[[Category: complex (nuclear protein/rna)]]
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[[Category: Ribonucleoprotein]]
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[[Category: ribonucleoprotein]]
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[[Category: Rna]]
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[[Category: rna]]
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[[Category: Snrnp]]
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[[Category: snrnp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:01:05 2008''
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Revision as of 07:01, 2 May 2008

Image:1a9n.jpg

Template:STRUCTURE 1a9n

CRYSTAL STRUCTURE OF THE SPLICEOSOMAL U2B-U2A' PROTEIN COMPLEX BOUND TO A FRAGMENT OF U2 SMALL NUCLEAR RNA


Overview

We have determined the crystal structure at 2.4 A resolution of a ternary complex between the spliceosomal U2B"/U2A' protein complex and hairpin-loop IV of U2 small nuclear RNA. Unlike its close homologue the U1A protein, U2B" binds to its cognate RNA only in the presence of U2A', which contains leucine-rich repeats in its sequence. The concave surface of a parallel beta-sheet within the leucine-rich-repeat region of U2A' interacts with the ribonucleoprotein domain of U2B" on the surface opposite its RNA-binding surface. The basic carboxy-terminal region of U2A' interacts with the RNA stem. The crystal structure reveals how protein-protein interaction regulates RNA-binding specificity, and how replacing only a few key residues allows the U2B" and U1A proteins to discriminate between their cognate RNA hairpins by forming alternative networks of interactions.

About this Structure

1A9N is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA., Price SR, Evans PR, Nagai K, Nature. 1998 Aug 13;394(6694):645-50. PMID:9716128 Page seeded by OCA on Fri May 2 10:01:05 2008

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