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5wd8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Legionella pneumophila effector lpg2328== | |
| + | <StructureSection load='5wd8' size='340' side='right'caption='[[5wd8]], [[Resolution|resolution]] 1.94Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5wd8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_570-co-h Legionella pneumophila subsp. pneumophila 570-co-h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WD8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lp12_2320 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=933093 Legionella pneumophila subsp. pneumophila 570-CO-H])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wd8 OCA], [http://pdbe.org/5wd8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wd8 RCSB], [http://www.ebi.ac.uk/pdbsum/5wd8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wd8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Legionella pneumophila is a pathogen causing severe pneumonia in humans called Legionnaires' disease. Lem22 is a previously uncharacterized effector protein conserved in multiple Legionella strains. Here, we report the crystal structure of Lem22 from the Philadelphia strain, also known as lpg2328, at 1.40 A resolution. The structure shows an up-and-down three-helical bundle with a significant structural similarity to a number of protein-binding domains involved in apoptosis and membrane trafficking. Sequence conservation identifies a putative functional site on the interface of helices 2 and 3. The structure is an important step toward a functional characterization of Lem22. | ||
| - | + | Crystal structure of the Legionella effector Lem22.,Kozlov G, Wong K, Gehring K Proteins. 2017 Nov 21. doi: 10.1002/prot.25427. PMID:29159828<ref>PMID:29159828</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5wd8" style="background-color:#fffaf0;"></div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Legionella pneumophila subsp. pneumophila 570-co-h]] | ||
| + | [[Category: Structural genomic]] | ||
[[Category: Gehring, K]] | [[Category: Gehring, K]] | ||
| - | [[Category: | + | [[Category: Kozlov, G]] |
[[Category: Wong, K]] | [[Category: Wong, K]] | ||
| + | [[Category: Bacterial effector]] | ||
| + | [[Category: Bsgi]] | ||
| + | [[Category: Legionella]] | ||
| + | [[Category: Protein binding]] | ||
Current revision
Crystal structure of Legionella pneumophila effector lpg2328
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