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6bdu
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of PprA from Deinococcus radiodurans== | |
| - | + | <StructureSection load='6bdu' size='340' side='right'caption='[[6bdu]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bdu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Deira Deira]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BDU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | [[Category: | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pprA, DR_A0346 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243230 DEIRA])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bdu OCA], [http://pdbe.org/6bdu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bdu RCSB], [http://www.ebi.ac.uk/pdbsum/6bdu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bdu ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PPRA_DEIRA PPRA_DEIRA]] dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end-joining (NHEJ) pathway for the repair of radiation-induced DNA double-strands breaks. Cannot bind to dsDNA without strand breaks or single-stranded DNA.<ref>PMID:15454524</ref> <ref>PMID:15458422</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Deira]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Czerwinski, M]] | [[Category: Czerwinski, M]] | ||
| - | [[Category: Junop, M | + | [[Category: Junop, M S]] |
[[Category: Szabla, R]] | [[Category: Szabla, R]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Dna damage repair]] | ||
| + | [[Category: Filment formation]] | ||
| + | [[Category: Genome segregation]] | ||
| + | [[Category: Radiation induced]] | ||
Current revision
Crystal structure of PprA from Deinococcus radiodurans
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