This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6ed7
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6ed7 is ON HOLD Authors: Brown, C.M., Zlitni, S., Chan, J., Brown, E.D., Junop, M.S. Description: Crystal structure of 7,8-diaminopelargonic acid s...) |
|||
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of 7,8-diaminopelargonic acid synthase bound to inhibitor MAC13772== | |
| - | + | <StructureSection load='6ed7' size='340' side='right'caption='[[6ed7]], [[Resolution|resolution]] 2.43Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ed7]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ED7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ED7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=J4J:2-[(2-nitrophenyl)sulfanyl]acetohydrazide'>J4J</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | |
| - | [[Category: | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bioA, EL75_3021, EL79_3111, EL80_3072 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine--8-amino-7-oxononanoate_transaminase Adenosylmethionine--8-amino-7-oxononanoate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.62 2.6.1.62] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ed7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ed7 OCA], [http://pdbe.org/6ed7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ed7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ed7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ed7 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A0A0A0GYM0_ECOLX A0A0A0GYM0_ECOLX]] Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.[HAMAP-Rule:MF_00834] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus coli migula 1895]] | ||
| + | [[Category: Adenosylmethionine--8-amino-7-oxononanoate transaminase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brown, C M]] | ||
| + | [[Category: Brown, E D]] | ||
| + | [[Category: Chan, J]] | ||
| + | [[Category: Junop, M S]] | ||
[[Category: Zlitni, S]] | [[Category: Zlitni, S]] | ||
| - | [[Category: | + | [[Category: Antibiotic]] |
| - | [[Category: | + | [[Category: Inhibitor adduct complex]] |
| - | [[Category: | + | [[Category: Transferase-antibiotic complex]] |
| - | + | ||
Current revision
Crystal structure of 7,8-diaminopelargonic acid synthase bound to inhibitor MAC13772
| |||||||||||
