1aa7
From Proteopedia
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'''INFLUENZA VIRUS MATRIX PROTEIN CRYSTAL STRUCTURE AT PH 4.0''' | '''INFLUENZA VIRUS MATRIX PROTEIN CRYSTAL STRUCTURE AT PH 4.0''' | ||
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[[Category: Luo, M.]] | [[Category: Luo, M.]] | ||
[[Category: Sha, B.]] | [[Category: Sha, B.]] | ||
| - | [[Category: | + | [[Category: Matrix protein]] |
| - | [[Category: | + | [[Category: Transcription repressor]] |
| - | [[Category: | + | [[Category: Viral assembly]] |
| - | [[Category: | + | [[Category: Virion budding]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:02:26 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:02, 2 May 2008
INFLUENZA VIRUS MATRIX PROTEIN CRYSTAL STRUCTURE AT PH 4.0
Overview
Matrix protein (M1) of influenza virus is a bifunctional protein that mediates the encapsidation of RNA-nucleoprotein cores into the membrane envelope. It is therefore required that M1 binds both membrane and RNA simultaneously. The X-ray crystal structure of the N-terminal portion of type A influenza virus M1-amino acid residues 2-158-has been determined at 2.08 A resolution at pH 4.0. The protein forms a dimer. A highly positively charged region on the dimer surface is suitably positioned to bind RNA while the hydrophobic surface opposite the RNA binding region may be involved in interactions with the membrane. The membrane-binding hydrophobic surface could be buried or exposed after a conformational change.
About this Structure
1AA7 is a Single protein structure of sequence from Unidentified influenza virus. Full crystallographic information is available from OCA.
Reference
Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1., Sha B, Luo M, Nat Struct Biol. 1997 Mar;4(3):239-44. PMID:9164466 Page seeded by OCA on Fri May 2 10:02:26 2008
