1aar
From Proteopedia
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'''STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2)''' | '''STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2)''' | ||
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[[Category: Jeffrey, L C.]] | [[Category: Jeffrey, L C.]] | ||
[[Category: Pickart, C M.]] | [[Category: Pickart, C M.]] | ||
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Revision as of 07:03, 2 May 2008
STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2)
Overview
Covalent ligation of multiubiquitin chains targets eukaryotic proteins for degradation. In such multiubiquitin chains, successive ubiquitins are linked by an isopeptide bond involving the side chain of Lys48 and the carboxyl group of Gly76. The crystal structure of a diubiquitin conjugate has been determined and refined at 2.3-A resolution. The molecule has internal approximate 2-fold symmetry with multiple hydrophobic and hydrophilic contacts along the 2-fold axis. The structure of the diubiquitin conjugate suggests determinants for recognition of multiubiquitin chains. A model for the interaction of diubiquitin and a ubiquitin conjugating enzyme (E2) is proposed.
About this Structure
1AAR is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2)., Cook WJ, Jeffrey LC, Carson M, Chen Z, Pickart CM, J Biol Chem. 1992 Aug 15;267(23):16467-71. PMID:1322903 Page seeded by OCA on Fri May 2 10:03:20 2008
