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User:Ivan E. Wang/Sandbox 1

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== Exogenous Ligand ==
== Exogenous Ligand ==
=== (''R'')-Emixustat (ACU-4429) ===
=== (''R'')-Emixustat (ACU-4429) ===
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<StructureSection load='4rry' size='340' side='right' caption='(''R'')-emixustat bound in the active site of RPE65' scene=''>
(''R'')-emixustat (ACU-4429) is an investigational small molecule inhibitor of RPE65 first invented by a British-American chemist, Ian L. Scott. Formulated as an hydrochloride salt, (''R'')-emixustat hydrochloride is taken by mouth and functions as a visual cycle modulator (VCM) to reduce toxic retinal byproducts such as A2E.
(''R'')-emixustat (ACU-4429) is an investigational small molecule inhibitor of RPE65 first invented by a British-American chemist, Ian L. Scott. Formulated as an hydrochloride salt, (''R'')-emixustat hydrochloride is taken by mouth and functions as a visual cycle modulator (VCM) to reduce toxic retinal byproducts such as A2E.
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=== (''S'')-Emixustat ===
=== (''S'')-Emixustat ===
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<StructureSection load='4ryz' size='340' side='right' caption='(''S'')-emixustat bound in the active site of RPE65' scene=''>
== ''R/S'' Enantiomers Differences ==
== ''R/S'' Enantiomers Differences ==

Revision as of 21:29, 28 January 2020

Retinal Pigment Epithelium 65 (Retinoid Isomerohydrolase) complex with (R/S)-emixustat and palmitate

Emixustat bound in the active site of RPE65

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

Proteopedia Page Contributors and Editors (what is this?)

Ivan E. Wang

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