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6l3f

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'''Unreleased structure'''
 
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The entry 6l3f is ON HOLD until Paper Publication
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==The structure of UTP:RNA uridylyltransferase 1 (URT1) in in Arabidopsis==
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<StructureSection load='6l3f' size='340' side='right'caption='[[6l3f]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6l3f]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L3F FirstGlance]. <br>
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Description:
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_uridylyltransferase RNA uridylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.52 2.7.7.52] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l3f OCA], [http://pdbe.org/6l3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l3f RCSB], [http://www.ebi.ac.uk/pdbsum/6l3f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l3f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/URT1_ARATH URT1_ARATH]] UTP:RNA uridylyltransferase with a marked preference for uridine polymerization and a distributive activity for the first added nucleotides (PubMed:23748567, PubMed:25928405). Uridylates oligo(A)-tailed mRNAs to prevent 3' to 5' ribonucleotytic attacks (PubMed:23748567). Can prevent the 3' trimming of mRNAs still engaged on polysomes (PubMed:23748567). Acts synergistically with HESO1 in unmethylated miRNA uridylation, leading to their degradation (PubMed:25928341). URT1 and HESO1 prefer substrates with different 3' end nucleotides and act cooperatively to tail different forms of the same miRNAs (PubMed:25928405). URT1 and HESO1 act sequentially, with URT1 mono-uridylating the miRNAs followed by their further uridylation by HESO1 (PubMed:25928405). Has no effect on uridylation of heterochromatic siRNAs (PubMed:25928341). Able to act on AGO1-bound miRNAs and the uridylated species stay associated with AGO1 (PubMed:25928405).<ref>PMID:23748567</ref> <ref>PMID:25928341</ref> <ref>PMID:25928405</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: RNA uridylyltransferase]]
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[[Category: Lingru, Z]]
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[[Category: Terminal uridylyltransferase]]
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[[Category: Transferase]]

Revision as of 15:29, 29 January 2020

The structure of UTP:RNA uridylyltransferase 1 (URT1) in in Arabidopsis

PDB ID 6l3f

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