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6sdf
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==N-terminal SH3 domain of Grb2 protein== | |
| - | + | <StructureSection load='6sdf' size='340' side='right'caption='[[6sdf]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6sdf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SDF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sdf OCA], [http://pdbe.org/6sdf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sdf RCSB], [http://www.ebi.ac.uk/pdbsum/6sdf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sdf ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | + | == Function == | |
| - | [[ | + | [[http://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bezprozvanny, I B]] | ||
| + | [[Category: Bolgov, A A]] | ||
[[Category: Kim, M]] | [[Category: Kim, M]] | ||
| - | [[Category: | + | [[Category: Korban, S A]] |
| + | [[Category: Luzik, D A]] | ||
| + | [[Category: Rogacheva, O N]] | ||
| + | [[Category: Skrynnikov, N R]] | ||
| + | [[Category: Zhemkov, V A]] | ||
| + | [[Category: Grb2]] | ||
| + | [[Category: Growth factor]] | ||
| + | [[Category: Sh3-domain]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 15:38, 29 January 2020
N-terminal SH3 domain of Grb2 protein
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