6qh1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of Schizosaccharomyces pombe PCNA in complex with an Spd1 derived peptide== |
| - | + | <StructureSection load='6qh1' size='340' side='right'caption='[[6qh1]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6qh1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QH1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qh1 OCA], [http://pdbe.org/6qh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qh1 RCSB], [http://www.ebi.ac.uk/pdbsum/6qh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qh1 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PCNA_SCHPO PCNA_SCHPO]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. [[http://www.uniprot.org/uniprot/SPD1_SCHPO SPD1_SCHPO]] Regulates the ribonucleotide reductase activity through its mediation of the nuclear localization of suc22, the small subunit of the ribonucleotide reductase. Delays the progression of the G1-S phase transition, thereby ensuring the G1 phase is complete. Interacts with both p34 and the p34-p56 complex, although no direct inhibitory effect on the bound proteins has been demonstrated. The action of p14 may happen coincidentally with the cdc10 function or may happen downstream of this.<ref>PMID:11069778</ref> <ref>PMID:12695334</ref> <ref>PMID:16317005</ref> <ref>PMID:8887552</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kassem, N]] | ||
| + | [[Category: Kragelund, B B]] | ||
| + | [[Category: Nielsen, O]] | ||
| + | [[Category: Olsen, J G]] | ||
| + | [[Category: Prestel, A]] | ||
| + | [[Category: Cell cycle regulation]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Dna repair]] | ||
| + | [[Category: Dna replication]] | ||
| + | [[Category: Pcna-spd1 complex]] | ||
Revision as of 08:05, 5 February 2020
The structure of Schizosaccharomyces pombe PCNA in complex with an Spd1 derived peptide
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