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6sb4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of murine perforin-2 P2 domain crystal form 2== | |
| - | + | <StructureSection load='6sb4' size='340' side='right'caption='[[6sb4]], [[Resolution|resolution]] 3.17Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6sb4]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SB4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sb4 OCA], [http://pdbe.org/6sb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sb4 RCSB], [http://www.ebi.ac.uk/pdbsum/6sb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sb4 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MPEG1_MOUSE MPEG1_MOUSE]] Plays a key role in the innate immune response following bacterial infection by polymerizing and inserting into the bacterial surface to form pores (PubMed:26402460). By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (PubMed:30249808). Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (PubMed:23257510, PubMed:23753625, PubMed:26402460). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (PubMed:26831467). Required for the antibacterial activity of reactive oxygen species and nitric oxide (PubMed:26402460).<ref>PMID:23257510</ref> <ref>PMID:23753625</ref> <ref>PMID:26402460</ref> <ref>PMID:26831467</ref> <ref>PMID:30249808</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gilbert, R J.C]] | ||
| + | [[Category: Ginger, L]] | ||
| + | [[Category: Ni, T]] | ||
| + | [[Category: Yu, X]] | ||
| + | [[Category: Beta-hairpin]] | ||
| + | [[Category: Membrane binding]] | ||
| + | [[Category: P2 domain]] | ||
| + | [[Category: Pore-forming protein]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 08:09, 5 February 2020
Crystal structure of murine perforin-2 P2 domain crystal form 2
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