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Spermidine Synthase

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==Structural highlights ==
==Structural highlights ==
<scene name='49/497058/Cv/7'>SPS active site contains the substrate spermidine</scene><ref>PMID:18367445</ref>. Water molecules are shown as red spheres.
<scene name='49/497058/Cv/7'>SPS active site contains the substrate spermidine</scene><ref>PMID:18367445</ref>. Water molecules are shown as red spheres.
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==3D structures of spermidine synthase==
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[[Spermidine synthase 3D structures]]
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</StructureSection>
</StructureSection>
==3D structures of spermidine synthase==
==3D structures of spermidine synthase==
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*Spermidine synthase
*Spermidine synthase
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**[[2o05]], [[2o06]], [[2o07]], [[2o0l]] – SPS – human<br />
**[[1inl]] – TmSPS – ''Thermotoga maritima''<br />
**[[1inl]] – TmSPS – ''Thermotoga maritima''<br />
**[[1mjf]] – SPS – ''Pyrococcus furiosus''<br />
**[[1mjf]] – SPS – ''Pyrococcus furiosus''<br />
**[[2e5w]], [[2zsu]] - SPS – ''Pyrococcus horikishii''<br />
**[[2e5w]], [[2zsu]] - SPS – ''Pyrococcus horikishii''<br />
**[[1iy9]] – SPS – ''Bacillus subtilis''<br />
**[[1iy9]] – SPS – ''Bacillus subtilis''<br />
-
**[[1xj5]], [[2q41]] – SPS – ''Arabidopsis thaliana''<br />
+
**[[1xj5]], [[2q41]], [[6o63]] – AtSPS 1 – ''Arabidopsis thaliana''<br />
 +
**[[6o64]] – AtSPS 2<br />
**[[2b2c]] – SPS – ''Caenorhabditis elegans''<br />
**[[2b2c]] – SPS – ''Caenorhabditis elegans''<br />
-
**[[2o05]], [[2o06]], [[2o07]], [[2o0l]] – SPS – human<br />
 
**[[2cmg]], [[2cmh]] – SPS – ''Helicobacter pylori''<br />
**[[2cmg]], [[2cmh]] – SPS – ''Helicobacter pylori''<br />
**[[2pss]] – PfSPS – ''Plasmodium falciparum''<br />
**[[2pss]] – PfSPS – ''Plasmodium falciparum''<br />
**[[3o4f]] – SPS – ''Escherichia coli''<br />
**[[3o4f]] – SPS – ''Escherichia coli''<br />
-
**[[3bwc]] - TcSPS – ''Trypanosoma cruzi''<br />
+
**[[3bwb]] - TcSPS – ''Trypanosoma cruzi''<br />
*Binary complexes of spermidine synthase
*Binary complexes of spermidine synthase
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**[[3rw9]] - hSPS + SAH<br />
 +
**[[6o65]] – AtSPS 1 + SAM<br />
**[[1jq3]] – TmSPS + transition state analog<br />
**[[1jq3]] – TmSPS + transition state analog<br />
**[[2hte]], [[2pt6]] - PfSPS + methylthioadenosine <br />
**[[2hte]], [[2pt6]] - PfSPS + methylthioadenosine <br />
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**[[2pwp]] - PfSPS + spermidine<br />
**[[2pwp]] - PfSPS + spermidine<br />
**[[3b7p]] - PfSPS + spermine<br />
**[[3b7p]] - PfSPS + spermine<br />
 +
**[[6i1n]], [[6hy1]] – PfSPS + cyclohexane derivative<br />
**[[3bwc]] - TcSPS + SAM <br />
**[[3bwc]] - TcSPS + SAM <br />
-
**[[3rw9]] - hSPS + SAH<br />
+
**[[3anx]] – TtSPS + methylthioadenosine – ''Thermus thermophilus''<br />
-
**[[3anx]] – SPS + methylthioadenosine – ''Thermus thermophilus''<br />
+
*Ternary complexes of spermidine synthase
*Ternary complexes of spermidine synthase
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**[[4cwa]], [[5b1s]] - PfSPS + inhibitor + ethanol derivative<br />
**[[4cwa]], [[5b1s]] - PfSPS + inhibitor + ethanol derivative<br />
**[[4yv0]], [[4yv1]], [[4yv2]], [[4yuv]], [[4yuw]], [[4yux]], [[4yuy]], [[4yuz]] - TcSPS + inhibitor + SAM derivative<br />
**[[4yv0]], [[4yv1]], [[4yv2]], [[4yuv]], [[4yuw]], [[4yux]], [[4yuy]], [[4yuz]] - TcSPS + inhibitor + SAM derivative<br />
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*N(4) – Bis(aminopropyl) spermidine synthase or branched-chain polyamine synthase
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**[[5xnf]] – TkBPSA – ''Thermococcus kodakarensis''<br />
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**[[5xnh]] – TkBPSA + spermidine <br />
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**[[5xnc]], [[6j26]] – TkBPSA + N4-aminopropylspermidine + methylthioadenosine <br />
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**[[6j27]] – TtBPSA + N4-aminopropylspermidine + methylthioadenosine <br />
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**[[6j28]] – TtBPSA (mutant) + N4-aminopropylspermidine + methylthioadenosine <br />
}}
}}

Revision as of 10:15, 9 February 2020

Structure of human spermidine synthase complex with spermidine and deoxymethyladenosine (PDB entry 3c6k)

Drag the structure with the mouse to rotate

3D structures of spermidine synthase

Updated on 09-February-2020

References

  1. ↑ Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN. Structure and mechanism of spermidine synthases. Biochemistry. 2007 Jul 17;46(28):8331-9. Epub 2007 Jun 22. PMID:17585781 doi:http://dx.doi.org/10.1021/bi602498k
  2. ↑ Schwartz CE, Wang X, Stevenson RE, Pegg AE. Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome). Methods Mol Biol. 2011;720:437-45. doi: 10.1007/978-1-61779-034-8_28. PMID:21318891 doi:http://dx.doi.org/10.1007/978-1-61779-034-8_28
  3. ↑ Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN. Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J Biol Chem. 2008 Jun 6;283(23):16135-46. Epub 2008 Mar 26. PMID:18367445 doi:http://dx.doi.org/10.1074/jbc.M710323200

Created with the participation of Lindsey Butler.

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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