This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Symporter
From Proteopedia
(Difference between revisions)
| Line 8: | Line 8: | ||
== Structural highlights == | == Structural highlights == | ||
Dipeptide: <scene name='70/705726/Cv/5'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>. | Dipeptide: <scene name='70/705726/Cv/5'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>. | ||
| + | |||
| + | == 3D Structures of symporter == | ||
| + | [[Symporter 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
| Line 18: | Line 22: | ||
**[[4ja4]], [[4qiq]] – EcSymp – ''Escherichia coli''<BR /> | **[[4ja4]], [[4qiq]] – EcSymp – ''Escherichia coli''<BR /> | ||
| - | **[[4ja3]] – EcSymp (mutant) <BR /> | + | **[[4ja3]], [[6n3i]] – EcSymp (mutant) <BR /> |
**[[4gby]] – EcSymp + xylose <BR /> | **[[4gby]] – EcSymp + xylose <BR /> | ||
**[[4gbz]], [[4gc0]] – EcSymp + glucose derivative<BR /> | **[[4gbz]], [[4gc0]] – EcSymp + glucose derivative<BR /> | ||
| Line 30: | Line 34: | ||
*Oligopeptide/H+ symporter | *Oligopeptide/H+ symporter | ||
| - | **[[4lep]], [[4tph]] – SoSymp – ''Shewanella oneidensis''<BR /> | + | **[[4lep]], [[4tph]], [[6jkc]], [[6jkd]] – SoSymp – ''Shewanella oneidensis''<BR /> |
| - | **[[2xut]] – SoSymp (mutant) <BR /> | + | **[[6ji1]] – SoSymp – Cryo EM<BR />**[[2xut]] – SoSymp (mutant) <BR /> |
**[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR /> | **[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR /> | ||
| Line 45: | Line 49: | ||
**[[3o7q]] – EcSymp <BR /> | **[[3o7q]] – EcSymp <BR /> | ||
**[[3o7p]] – EcSymp (mutant)<BR /> | **[[3o7p]] – EcSymp (mutant)<BR /> | ||
| + | |||
| + | *Succinate-acetate/H+ symporter | ||
| + | |||
| + | **[[5zug]] – EcSymp <BR /> | ||
*Lactose/H+ symporter | *Lactose/H+ symporter | ||
| Line 62: | Line 70: | ||
**[[5x9r]], [[5xas]], [[5xat]] – KpSymp + citrate + Na – ''Klebsiella pneumoniae''<BR /> | **[[5x9r]], [[5xas]], [[5xat]] – KpSymp + citrate + Na – ''Klebsiella pneumoniae''<BR /> | ||
**[[4bpq]], [[5xar]] – KpSymp <BR /> | **[[4bpq]], [[5xar]] – KpSymp <BR /> | ||
| + | |||
| + | *Sodium/alanine symporter | ||
| + | |||
| + | **[[6csf]], [[6cse]] – Symp + antibody + alanine – ''Methanococcus maripaludis''<BR /> | ||
| + | |||
| + | *Sodium/aspartate symporter | ||
| + | |||
| + | **[[6bat]] – PhSymp + aspartate – ''Pyrococcus horikoshi''i<BR /> | ||
| + | **[[6bav]], [[6bau]] – PhSymp (mutant) + cysteine derivative<BR /> | ||
| + | **[[6bmi]] – PhSymp (mutant) + serine<BR /> | ||
| + | |||
| + | *Sodium/glutamate symporter | ||
| + | |||
| + | **[[4p6h]], [[4p3j]], [[4p1a]], [[3v8g]], [[3v8f]] – PhSymp <BR /> | ||
*Neurotransmitter/leucine symporter LeuT | *Neurotransmitter/leucine symporter LeuT | ||
Revision as of 10:37, 12 February 2020
| |||||||||||
3D Structures of symporter
Updated on 12-February-2020
References
- ↑ Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003 Feb;24(1):48-77. PMID:12588808 doi:http://dx.doi.org/10.1210/er.2001-0029
- ↑ Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie. 1999 May;81(5):469-76. PMID:10403177
- ↑ Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, Caffrey M, Newstead S. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep. 2014 Jun 10. pii: e201338403. PMID:24916388 doi:http://dx.doi.org/10.15252/embr.201338403
