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Syntaxin

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<StructureSection load='3ipd' size='340' side='right' caption='Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (grey) and SNAP25 SNARE motif (pink and yellow) (PDB code [[3ipd]])' scene=''>
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<StructureSection load='3ipd' size='450' side='right' caption='Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code [[3ipd]])' scene='80/801795/Cv/5'>
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions<ref>PMID:19571812</ref>.
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<scene name='80/801795/Cv/8'>Syntaxin 1a SNARE motif complex with VAMP2 SNARE motif and SNAP25 SNARE motif</scene> (PDB code [[3hd7]]). The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions<ref>PMID:19571812</ref>. <scene name='80/801795/Cv/0'>The interactions of the syntaxin 1a with AMP2 SNARE motif and SNAP25 SNARE motives</scene> (PDB code [[3ipd]]).
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</StructureSection>
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==3D structures of syntaxin==
==3D structures of syntaxin==
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[[Syntaxin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Syntaxin 1
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**[[2xhe]] – Stx1 + Unc18 – Monosiga brevicollis<br />
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*Syntaxin 1A
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**[[1ez3]] – rStx1a N-terminal – rat<br />
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**[[1br0]] – rStx1a N-terminal (mutant) – NMR<br />
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**[[1hvv]] – rStx1a SNARE motif<br />
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**[[2m8r]] – rStx1a SNARE motif - NMR<br />
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**[[1jth]] – rStx1a SNARE motif + SNAP25<br />
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**[[1urq]] – rStx1a SNARE motif + SNAP25 + tomosyn<br />
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**[[1n7s]], [[3h7d]], [[1sfc]], [[3ipd]], [[3rk2]], [[3rl0]] – rStx1a SNARE motif + SNAP25 + VAMP2<br />
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**[[3rk3]] – rStx1a SNARE motif + SNAP25 + complexin-1 + VAMP2<br />
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**[[5ccg]], [[5cch]], [[5cci]], [[5kj7]], [[5kj8]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 <br />
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**[[2n1t]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 - NMR<br />
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**[[3c98]], [[4jeh]], [[4jeu]] – rStx1a + Unc18 <br />
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*Syntaxin 6
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**[[1lvf]] – rStx6 N-terminal <br />
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**[[4j2c]] – hStx6 + vacuolar protein sorting-associated protein peptide – human<br />
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*Syntaxin 7
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**[[1gl2]] – mStx7 core fragment + VAMP8 + rStx8 core fragment + VTI1-RP2 - mouse <br />
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*Syntaxin 10
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**[[4dnd]] – hStx10 <br />
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*Syntaxin 12
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**[[2dnx]] – hStx12 N-terminal - NMR<br />
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*Syntaxin 13
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**[[2nps]] – rStx13 SNARE motif + VAMP2 + hStx6 SNARE motif + VTI1-RP2 <br />
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*Syntaxin 17
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**[[4wy4]] – rStx17 SNARE motif + SNAP25 + VAMP2<br />
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*s-syntaxin
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**[[1s94]] – LpStx Habc domain – Loligo pealei<br />
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**[[1l4a]] – LpStx1a SNARE motif + SNAP25 + synaptobrevin + synaphin A<br />
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*Syntaxin VAM3
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**[[1hs7]] – Stx N-terminal – yeast - NMR<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code 3ipd)

Drag the structure with the mouse to rotate

References

  1. ↑ Hussain S, Ringsevjen H, Egbenya DL, Skjervold TL, Davanger S. SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus. Front Mol Neurosci. 2016 Feb 5;9:10. doi: 10.3389/fnmol.2016.00010. eCollection, 2016. PMID:26903802 doi:http://dx.doi.org/10.3389/fnmol.2016.00010
  2. ↑ Liang B, Kiessling V, Tamm LK. Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate. Proc Natl Acad Sci U S A. 2013 Nov 11. PMID:24218570 doi:http://dx.doi.org/10.1073/pnas.1314699110
  3. ↑ Hussain S, Ringsevjen H, Egbenya DL, Skjervold TL, Davanger S. SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus. Front Mol Neurosci. 2016 Feb 5;9:10. doi: 10.3389/fnmol.2016.00010. eCollection, 2016. PMID:26903802 doi:http://dx.doi.org/10.3389/fnmol.2016.00010
  4. ↑ Stein A, Weber G, Wahl MC, Jahn R. Helical extension of the neuronal SNARE complex into the membrane. Nature. 2009 Jul 23;460(7254):525-8. Epub 2009 Jul 1. PMID:19571812 doi:10.1038/nature08156

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Michal Harel, Alexander Berchansky

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