1aih

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[[Image:1aih.gif|left|200px]]
[[Image:1aih.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1aih |SIZE=350|CAPTION= <scene name='initialview01'>1aih</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1aih", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ACA:Active+Site'>ACA</scene>, <scene name='pdbsite=ACB:Active+Site'>ACB</scene>, <scene name='pdbsite=ACC:Active+Site'>ACC</scene> and <scene name='pdbsite=ACD:Active+Site'>ACD</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= GENBANK U24159 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10690 Haemophilus phage HP1])
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-->
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|DOMAIN=
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{{STRUCTURE_1aih| PDB=1aih | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aih OCA], [http://www.ebi.ac.uk/pdbsum/1aih PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aih RCSB]</span>
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}}
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'''CATALYTIC DOMAIN OF BACTERIOPHAGE HP1 INTEGRASE'''
'''CATALYTIC DOMAIN OF BACTERIOPHAGE HP1 INTEGRASE'''
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[[Category: Scocca, J J.]]
[[Category: Scocca, J J.]]
[[Category: Waninger, S.]]
[[Category: Waninger, S.]]
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[[Category: dna integration]]
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[[Category: Dna integration]]
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[[Category: recombination]]
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[[Category: Recombination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:18:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:40:55 2008''
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Revision as of 07:18, 2 May 2008

Image:1aih.gif

Template:STRUCTURE 1aih

CATALYTIC DOMAIN OF BACTERIOPHAGE HP1 INTEGRASE


Overview

HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenzae. The isolated C-terminal domain (residues 165-337) of the protein interacts with the recombination site and contains the four catalytic residues conserved in the integrase family. This domain represents a novel fold consisting principally of well-packed alpha helices, a surface beta sheet, and an ordered 17-residue C-terminal tail. The conserved triad of basic residues and the active-site tyrosine are contributed by a single monomer and occupy fixed positions in a defined active-site cleft. Dimers are formed by mutual interactions of the tail of one monomer with an adjacent monomer; this orients active-site clefts antiparallel to each other.

About this Structure

1AIH is a Single protein structure of sequence from Haemophilus phage hp1. Full crystallographic information is available from OCA.

Reference

Molecular organization in site-specific recombination: the catalytic domain of bacteriophage HP1 integrase at 2.7 A resolution., Hickman AB, Waninger S, Scocca JJ, Dyda F, Cell. 1997 Apr 18;89(2):227-37. PMID:9108478 Page seeded by OCA on Fri May 2 10:18:41 2008

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