1ajv

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[[Image:1ajv.jpg|left|200px]]
[[Image:1ajv.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ajv |SIZE=350|CAPTION= <scene name='initialview01'>1ajv</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1ajv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NMB:2,7-DIBENZYL-1,1-DIOXO-3,6-BIS-PHENOXYMETHYL-[1,2,7]THIADIAZEPANE-4,5-DIOL'>NMB</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PROTEASE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Human immunodeficiency virus type 1 (isolate 12)])
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-->
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|DOMAIN=
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{{STRUCTURE_1ajv| PDB=1ajv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ajv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ajv OCA], [http://www.ebi.ac.uk/pdbsum/1ajv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ajv RCSB]</span>
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}}
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'''HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006'''
'''HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006'''
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Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor., Backbro K, Lowgren S, Osterlund K, Atepo J, Unge T, Hulten J, Bonham NM, Schaal W, Karlen A, Hallberg A, J Med Chem. 1997 Mar 14;40(6):898-902. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9083478 9083478]
Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor., Backbro K, Lowgren S, Osterlund K, Atepo J, Unge T, Hulten J, Bonham NM, Schaal W, Karlen A, Hallberg A, J Med Chem. 1997 Mar 14;40(6):898-902. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9083478 9083478]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
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[[Category: Human immunodeficiency virus type 1 (isolate 12)]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Backbro, K.]]
[[Category: Backbro, K.]]
[[Category: Unge, T.]]
[[Category: Unge, T.]]
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[[Category: aspartyl protease]]
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[[Category: Aspartyl protease]]
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[[Category: drug design]]
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[[Category: Drug design]]
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[[Category: hiv-1]]
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[[Category: Hiv-1]]
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[[Category: non-peptide inhibitor]]
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[[Category: Non-peptide inhibitor]]
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[[Category: protease]]
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[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:21:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:41:51 2008''
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Revision as of 07:21, 2 May 2008

Image:1ajv.jpg

Template:STRUCTURE 1ajv

HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006


Overview

Two cyclic, C2-symmetric HIV-1 protease inhibitors, one sulfamide and one urea derivative, both comprising phenyl ether groups in the P1/P1' positions, were cocrystallized with HIV-1 protease, and the crystal structures were determined to 2.0 A resolution. The structure of the urea 2 showed a conformation similar to that reported for the related urea 3 by Lam et al., while the sulfamide 1 adopted an unanticipated conformation in which the P1' and P2' side chains were transposed.

About this Structure

1AJV is a Single protein structure of sequence from Human immunodeficiency virus type 1 (isolate 12). Full crystallographic information is available from OCA.

Reference

Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor., Backbro K, Lowgren S, Osterlund K, Atepo J, Unge T, Hulten J, Bonham NM, Schaal W, Karlen A, Hallberg A, J Med Chem. 1997 Mar 14;40(6):898-902. PMID:9083478 Page seeded by OCA on Fri May 2 10:21:56 2008

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OCA

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