1ak4

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[[Image:1ak4.jpg|left|200px]]
[[Image:1ak4.jpg|left|200px]]
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{{Structure
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|PDB= 1ak4 |SIZE=350|CAPTION= <scene name='initialview01'>1ak4</scene>, resolution 2.36&Aring;
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The line below this paragraph, containing "STRUCTURE_1ak4", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
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|GENE= CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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|DOMAIN=
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{{STRUCTURE_1ak4| PDB=1ak4 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ak4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ak4 OCA], [http://www.ebi.ac.uk/pdbsum/1ak4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ak4 RCSB]</span>
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'''HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID'''
'''HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID'''
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[[Category: Vajdos, F F.]]
[[Category: Vajdos, F F.]]
[[Category: Worthylake, D K.]]
[[Category: Worthylake, D K.]]
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[[Category: capsid]]
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[[Category: Capsid]]
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[[Category: cyclophilin some]]
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[[Category: Cyclophilin some]]
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[[Category: hiv-1]]
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[[Category: Hiv-1]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: rotamase complex (capsid protein/cyclosporin)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:22:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:42:12 2008''
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Revision as of 07:22, 2 May 2008

Image:1ak4.jpg

Template:STRUCTURE 1ak4

HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID


Overview

The HIV-1 capsid protein forms the conical core structure at the center of the mature virion. Capsid also binds the human peptidyl prolyl isomerase, cyclophilin A, thereby packaging the enzyme into the virion. Cyclophilin A subsequently performs an essential function in HIV-1 replication, possibly helping to disassemble the capsid core upon infection. We report the 2.36 A crystal structure of the N-terminal domain of HIV-1 capsid (residues 1-151) in complex with human cyclophilin A. A single exposed capsid loop (residues 85-93) binds in the enzyme's active site, and Pro-90 adopts an unprecedented trans conformation. The structure suggests how cyclophilin A can act as a sequence-specific binding protein and a nonspecific prolyl isomerase. In the crystal lattice, capsid molecules assemble into continuous planar strips. Side by side association of these strips may allow capsid to form the surface of the viral core. Cyclophilin A could then function by weakening the association between capsid strips, thereby promoting disassembly of the viral core.

About this Structure

1AK4 is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid., Gamble TR, Vajdos FF, Yoo S, Worthylake DK, Houseweart M, Sundquist WI, Hill CP, Cell. 1996 Dec 27;87(7):1285-94. PMID:8980234 Page seeded by OCA on Fri May 2 10:22:21 2008

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