DNA repair protein

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== Structural highlights ==
== Structural highlights ==
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Rad4 β-hairpin inserts into DNA making hydrogen bond interactions as well as non-bonding interactions with it<ref>PMID:17882165</ref>.
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<scene name='78/780971/Cv/2'>tructure of yeast Rad4 complex with Rad23 and DNA</scene> (PDB entry [[2qsg]]). Rad4 β-hairpin inserts into DNA making hydrogen bond interactions as well as non-bonding interactions with it<ref>PMID:17882165</ref>.
</StructureSection>
</StructureSection>
== 3D Structures of DNA repair protein Rad4 ==
== 3D Structures of DNA repair protein Rad4 ==

Revision as of 14:32, 23 February 2020

Structure of yeast Rad4 (green) complex with Rad23 (magenta) and DNA (PDB entry 2qsg)

Drag the structure with the mouse to rotate

3D Structures of DNA repair protein Rad4

Updated on 23-February-2020

2qsf – yRad4 + Rad23 - yeast
2qsg, 2qsh, 4yir, 6cfi – yRad4 + Rad23 + DNA
2m14 – yRad4 internal UBA domain + RNA polymerase II TFB1 - NMR
4bu0, 4bu1, 6hm3, 6hm4 – fyRad4 BRCT1 domain + phosphopeptide – fission yeast
4bmc – fyRad4 BRCT1 + BRCT2 domains
4bmd – fyRad4 BRCT3 + BRCT4 domains

References

  1. ↑ den Dulk B, Brandsma JA, Brouwer J. The Rad4 homologue YDR314C is essential for strand-specific repair of RNA polymerase I-transcribed rDNA in Saccharomyces cerevisiae. Mol Microbiol. 2005 Jun;56(6):1518-26. doi: 10.1111/j.1365-2958.2005.04607.x. PMID:15916602 doi:http://dx.doi.org/10.1111/j.1365-2958.2005.04607.x
  2. ↑ Velmurugu Y, Chen X, Slogoff Sevilla P, Min JH, Ansari A. Twist-open mechanism of DNA damage recognition by the Rad4/XPC nucleotide excision repair complex. Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2296-305. doi:, 10.1073/pnas.1514666113. Epub 2016 Mar 31. PMID:27035942 doi:http://dx.doi.org/10.1073/pnas.1514666113
  3. ↑ Min JH, Pavletich NP. Recognition of DNA damage by the Rad4 nucleotide excision repair protein. Nature. 2007 Oct 4;449(7162):570-5. Epub 2007 Sep 19. PMID:17882165 doi:10.1038/nature06155
  4. ↑ Min JH, Pavletich NP. Recognition of DNA damage by the Rad4 nucleotide excision repair protein. Nature. 2007 Oct 4;449(7162):570-5. Epub 2007 Sep 19. PMID:17882165 doi:10.1038/nature06155

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