6lxt
From Proteopedia
(Difference between revisions)
m (Protected "6lxt" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of post fusion core of 2019-nCoV S2 subunit== | |
| - | + | <StructureSection load='6lxt' size='340' side='right'caption='[[6lxt]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6lxt]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LXT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6lxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lxt OCA], [http://pdbe.org/6lxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lxt RCSB], [http://www.ebi.ac.uk/pdbsum/6lxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lxt ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/D5HJT4_BCHK3 D5HJT4_BCHK3]] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sun, F]] | ||
[[Category: Zhu, Y]] | [[Category: Zhu, Y]] | ||
| - | [[Category: | + | [[Category: 2019-ncov]] |
| + | [[Category: Hr1 and hr2 domain]] | ||
| + | [[Category: Viral protein]] | ||
| + | [[Category: Virus]] | ||
Revision as of 09:16, 26 February 2020
Structure of post fusion core of 2019-nCoV S2 subunit
| |||||||||||
