6u5z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of E. coli LonA S679A== | |
| - | + | <StructureSection load='6u5z' size='340' side='right'caption='[[6u5z]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6u5z]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U5Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5z OCA], [http://pdbe.org/6u5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u5z RCSB], [http://www.ebi.ac.uk/pdbsum/6u5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5z ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/C3TLS2_ECOLX C3TLS2_ECOLX]] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system.[HAMAP-Rule:MF_01973] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Endopeptidase La]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Botos, I]] | ||
| + | [[Category: Lountos, G T]] | ||
| + | [[Category: Weimin, W]] | ||
| + | [[Category: Wlodawer, A]] | ||
| + | [[Category: Hexamer]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Lon protease]] | ||
Revision as of 09:26, 26 February 2020
Cryo-EM structure of E. coli LonA S679A
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