Thymidylate synthase

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</StructureSection>
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==3D structures of thymidylate synthase==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*'''Thymidylate synthase'''
 
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**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]], [[4up1]], [[5x5a]], [[5x69]][[3n5g]], [[4kpw]] - hTS – human<br />
 
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**[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]], [[4jef]], [[4o1u]], [[4o1x]], [[5x4w]], [[5x4x]], [[5x4y]], [[6qyq]] – hTS (mutant)<br />
 
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**[[3ihi]], [[6qyj]] – mTS – mouse<br />
 
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**[[4iqb]] – nTS – nematode<br />
 
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**[[3tms]], [[1tjs]], [[1f4b]], [[2ftq]] – EcTS – ''Escherichia coli''<br />
 
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**[[1ajm]], [[1bq2]], [[1qqq]], [[1ev5]], [[1ev8]], [[1evf]], [[1evg]], [[1ffl]], [[2g8x]], [[2ftn]] - EcTS (mutant) <br />
 
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**[[4tms]], [[1tda]] - LcTS – ''Lactobacillus casei''<br />
 
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**[[1tsw]], [[1tsz]] - LcTS (mutant)<br />
 
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**[[1tis]] – TS – ''Enterobacteria'' phage T4<br />
 
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**[[1bsf]], [[1bko]], [[1bkp]], [[1bsp]] - BsTS - ''Bacillus subtilis''<br />
 
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**[[3ix6]] – BmTS – ''Brucella melitensis''<br />
 
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**[[3kgb]] – TS – ''Encephalitozoon cuniculi''<br />
 
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**[[3v8h]] – TS – ''Burkholderia thailandensis''<br />
 
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**[[4h0r]] - CgTS – ''Corynebacterium glutamicum''<br />
 
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**[[4xse]] - VvTS – Varicella-zoster virus<br />
 
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**[[6auj]] - TS – ''Elizabethkingia anophelis''<br />
 
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*Thymidylate synthase binary complex
 
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**[[6qsh]] - hTS + dUMP<br />
 
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**[[3hb8]] - hTS (mutant) + UMP
 
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**[[6qxg]] - hTS + fluoro-dUMP<br />
 
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**[[3h9k]] - hTS (mutant) + fluoro-dUMP
 
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**[[5wrn]] - hTS + CMP<br />
 
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**[[3ob7]] - hTS (mutant) + glutathione<br />
 
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**[[4g2o]] – hTS (mutant) + purpurogallin<br />
 
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**[[4gd7]] – hTS + purpurogallin<br />
 
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**[[4g6w]] – hTS (mutant) + bromobenzine-triol<br />
 
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**[[3n5e]], [[4fgt]] - hTS + peptide inhibitor<br />
 
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**[[4e28]] - hTS + inhibitor<br />
 
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**[[6r2e]] – hTS (mutant) + folate derivative<br />
 
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**[[4e5o]] - mTS + UMP<br />
 
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**[[4ein]] – mTS + substrate analog<br />
 
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**[[4ez8]] – mTS + substrate analog + dihydrofolate<br />
 
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**[[4psg]] – nTS + inhibitor <br >
 
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**[[4irr]], [[4isw]] – nTS + UMP<br />
 
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**[[5by6]] – TwTS + UMP – Trichina worm<br />
 
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**[[1tmk]] - TS + TMP – yeast<br />
 
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**[[1tdc]], [[1thy]], [[2tdm]], [[5x5d]] – LcTS + UMP<BR />
 
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**[[1tsv]], [[1tsx]], [[1tsy]], [[1njd]], [[1njb]], [[1vza]], [[1vzb]], [[1jmf]], [[1jmg]], [[1jmh]], [[1jmi]], [[1bo7]], [[1bo8]], [[1bp6]], [[1bpj]], [[1bp0]], [[2g86]], [[2g89]], [[2g8a]], [[2g8d]] - LcTS (mutant) + UMP<BR />
 
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**[[1vzc]] - LcTS (mutant) + fluoro-UMP<BR />
 
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**[[1nja]], [[1njc]] - LcTS (mutant) + CMP<BR />
 
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**[[1nje]] - LcTS + CMP<BR />
 
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**[[1tdb]] - LcTS + fluoro-UMP<BR />
 
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**[[1tsl]], [[1tsm]] - LcTS + inhibitor<br />
 
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**[[4tmk]], [[5tmp]] - EcTS + inhibitor<br />
 
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**[[1an5]] - EcTS + inhibitor<br />
 
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**[[1fwm]] - EcTS (mutant) + inhibitor<br />
 
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**[[1bid]] - EcTS + UMP<BR />
 
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**[[1aob]], [[1bdu]] - EcTS + deoxyuridine derivative<br />
 
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**[[1f4c]], [[1f4e]] - EcTS + tosyl-proline derivative<br />
 
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**[[1f4d]] - EcTS (mutant) + tosyl-proline derivative<br />
 
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**[[1f4f]], [[1f4g]] - EcTS + glutamyl-proline derivative<br />
 
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**[[2vet]] - EcTS (mutant) + UMP<BR />
 
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**[[3b9h]] - EcTS + nitro-UMP<BR />
 
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**[[3bfi]] - EcTS (mutant) + nitro-UMP<BR />
 
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**[[4dq1]] - TS + UMP – ''Staphylococcus aureus''<br />
 
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**[[3uwl]] – EfTS + 5-formyl tetrahydrofolate – ''Enterococcus faecalis''<br >
 
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**[[6qya]] – EfTS + dUMP<br />
 
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**[[5j7w]] – EfTS + drug <br >
 
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**[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br />
 
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**[[4h0u]] – CgTS + UMP<br />
 
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**[[4xsc]] - VvTS + d-Uridine derivative <br />
 
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**[[4xsd]] - VvTS + dUMP<br />
 
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*Thymidylate synthase ternary complex
 
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**[[1hvy]], [[1i00]], [[5x5q]], [[5x66]], [[5x67]] - hTS + drug + UMP<br />
 
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**[[1e2d]], [[1e2e]], [[1e2f]] - hTS (mutant) + ADP + TMP<br />
 
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**[[5hs3]], [[6pf6]], [[6pf5]], [[6pf4]], [[6pf3]], [[6ojv]], [[6oju]] - hTS + inhibitor + dUMP<br />
 
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**[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor + UMP<br />
 
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**[[5fct]] - mTS + inhibitor + fluoro-UMP <br />
 
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**[[4eb4 - mTS + drug + UMP<br />
 
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**[[6f6z]] - mTS + folate derivative + CMP derivative <br />
 
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**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
 
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**[[4iqq]] – nTS + UMP + drug<br />
 
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**[[5noo]] - TS + drug + UMP – ''Caenorhabditis elegans''<br />
 
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**[[5m4z]] - TwTS + folate derivative + CMP derivative <br />
 
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**[[2tdd]] - LcTS + inhibitor+ fluoro-UMP<BR />
 
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**[[1vzd]] - LcTS (mutant) + inhibitor+ fluoro-UMP<BR />
 
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**[[1vze]], [[1tvu]], [[1tvv]], [[1tvw]] - LcTS (mutant) + inhibitor+ UMP<BR />
 
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**[[1lca]], [[1lce]], [[3bnz]] - LcTS + inhibitor+ UMP<BR />
 
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**[[1lcb]] - LcTS + inhibitor+ TMP<BR />
 
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**[[3byx]], [[3bz0]], [[3c06]], [[3c0a]], [[3ijz]], [[3ik0]], [[3ik1]] - LcTS + phthalimidic derivative + UMP<BR />
 
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**[[1tys]] - EcTS + inhibitor+ TMP<BR />
 
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**[[2fto]], [[3bgx]] - EcTS (mutant) + inhibitor+ TMP<BR />
 
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**[[1tlc]] - EcTS + inhibitor+ GMP<BR />
 
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**[[1syn]], [[1tsd]] - EcTS + inhibitor+ UMP<BR />
 
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**[[2bbq]], [[2tsc]], [[1kce]], [[1trg]], [[1kzi]], [[4isk]], [[4lrr]] - EcTS + inhibitor+ UMP<BR />
 
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**[[1zpr]], [[1aiq]], [[1dna]], [[1bq1]], [[1kzj]], [[2vf0]], [[3b5b]] - EcTS (mutant) + inhibitor+ UMP<BR />
 
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**[[1tls]], [[1tsn]] - EcTS + inhibitor+ fluoro-UMP<BR />
 
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**[[3bhl]], [[3bhr]] - EcTS + inhibitor+ nitro-UMP<BR />
 
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**[[1bjg]] - EcTS (mutant) + inhibitor+ fluoro-UMP<BR />
 
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**[[2kce]], [[1axw]] - EcTS + drug + UMP<BR />
 
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**[[1jtq]], [[1jtu]], [[1jut]], [[1jg0]], [[2a9w]] - EcTS + inhibitor+ UMP<BR />
 
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**[[1nce]] - EcTS (mutant) + inhibitor+ UMP<BR />
 
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**[[1ddu]], [[1tdu]] - EcTS + deoxyuridine derivative + inhibitor<br />
 
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**[[6cdz]] - EcTS + deoxyuridine + UMP<br />
 
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**[[4gev]] - EcTS + deoxyuridine derivative + cofactor analog<br />
 
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**[[6nnr]] - EcTS + deoxyuridine derivative + folate derivative<br />
 
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**[[1b02]] - BsTS + inhibitor+ fluoro-UMP<BR />
 
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**[[1ci7]] - PcTS + inhibitor+ UMP – ''Pneumocystis carinii''<br />
 
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**[[1f28]] - PcTS + inhibitor+ UMP<BR />
 
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**[[2aaz]] - TS + inhibitor+ UMP – ''Filobasidiella neoformans''<br />
 
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**[[3qj7]] - MtTS + spermine + UMP <br />
 
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**[[4fog]] - MtTS + fluoro-UMP + methy-DHF<br />
 
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**[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br />
 
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**[[4o7u]] - EfTS + phthalimidic derivative + folate derivative<br />
 
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**[[6qxs]] - EfTS + fluoro-dUMP + folate derivative<br />
 
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*'''Bifunctional dihydrofolate reductase-thymidylate synthase''' see [[Dihydrofolate reductase]]
 
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*'''Flavin-dependent thymidylate synthase ThyX'''
 
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**[[2af6]], [[3gwc]] - MtTS + FAD + halo-UMP<BR />
 
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**[[3hzg]] - MtTS + FAD <br />
 
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**[[2gq2]] - MtTS (mutant) + NADP<br />
 
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**[[2cfa]] - TS + FAD – ''Paramecium bursaria chlorella'' virus<br />
 
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**[[5jfe]] - TmTS + FAD + UMP – ''Thermotoga maritima''<br />
 
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**[[3g4a]], [[3g4c]], [[3n0b]], [[3n0c]] - TS (mutant) + FAD + UMP <br />
 
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**[[1o24]] – TmTS<br />
 
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**[[1o25]] – TmTS + UMP<br />
 
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**[[1o2a]] – TmTS + FAD <br />
 
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**[[4gtc]], [[4gtl]], [[4kar]] – TmTS (mutant) + FAD <br />
 
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**[[1o26]] – TmTS + FAD + UMP<br />
 
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**[[4gtd]], [[4kas]], [[4kat]], [[5iot]] – TmTS (mutant) + FAD + UMP<br />
 
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**[[1o27]], [[1o28]], [[1o29]] – TmTS + FAD + halo-UMP<br />
 
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**[[1o2b]] – TmTS + FAD + phosphate<br />
 
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**[[4gta]] – TmTS + FAD + UMP + folate derivative<br />
 
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**[[4gt9]] – TmTS + FAD + UMP + folate<br />
 
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**[[4gtf]] – TmTS (mutant) + FAD + UMP + folate<br />
 
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**[[4gte]] – TmTS (mutant) + FAD + folate<br />
 
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**[[4gtb]] – TmTS + FAD + UMP + drug<br />
 
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**[[5chp]] – TmTS + FAD + UMP + inhibitor<br />
 
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**[[5ioq]], [[5ior]] – TmTS + FAD + d-Uridine derivative<br />
 
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**[[5ios]], [[2iot]] – TmTS (mutant) + FAD + dUMP<br />
 
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**[[3ge9]] - CgTS<br />
 
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**[[3fnn]] - CgTS + FAD <br />
 
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**[[3ah5]], [[3n3y]] - TS + FAD + UMP – ''Helicobacter pylori''<br />
 
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**[[4p5a]], [[4p5b]] – TS + FAD + dUMP derivative – ''Streptomyces cacaoi''<br />
 
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**[[6j61]] - TS + FAD – ''Thermus thermophilus''<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:40, 26 February 2020

Thymidylate synthase complex with dUMP (PDB entry 1tsv)

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References

  1. ↑ Kaneda S, Nalbantoglu J, Takeishi K, Shimizu K, Gotoh O, Seno T, Ayusawa D. Structural and functional analysis of the human thymidylate synthase gene. J Biol Chem. 1990 Nov 25;265(33):20277-84. PMID:2243092
  2. ↑ Rahman L, Voeller D, Rahman M, Lipkowitz S, Allegra C, Barrett JC, Kaye FJ, Zajac-Kaye M. Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. Cancer Cell. 2004 Apr;5(4):341-51. PMID:15093541
  3. ↑ Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM. Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng. 1996 Jan;9(1):69-75. PMID:9053905
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