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Tissue factor

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(New page: <StructureSection load='2aer' size='340' side='right' caption='Structure of human tissue factor complex with coagulation factor VIIa heavy chain and light chain and ihibitor (PDB code [[2...)
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<StructureSection load='' size='350' side='right' caption='Structure of human tissue factor (green) complex with coagulation factor VIIa heavy chain (magenta) and light chain (deep sky blue) and Ca+2 ion (green) (PDB code [[1j9c]]).' scene='59/595166/Cv/1'>
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<StructureSection load='2aer' size='340' side='right' caption='Structure of human tissue factor complex with coagulation factor VIIa heavy chain and light chain and ihibitor (PDB code [[2aer]]).' scene=''>
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== Function ==
== Function ==
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'''Tissue factor''' (TF) is a high-affinity receptor for the blood coagulation factor VII. The TF/factor VII complex is responsible for the initiation of the coagulation protease cascade.
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'''Tissue factor''' (TF) is a high-affinity receptor for the blood coagulation factor VII. The TF/factor VII complex is responsible for the initiation of the coagulation protease cascade<ref>PMID:23809131</ref>.
== Disease ==
== Disease ==
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TF is involved in cancer angiogenesis and metastasis<ref>PMID:14614019</ref>.
== Relevance ==
== Relevance ==
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TF expression by cardiac myocytes is important to maintain heart hemostasis under normal and pathologic conditions<ref>PMID:17663739</ref>.
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== Structural highlights ==
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*<scene name='59/595166/Cv/3'>Human tissue factor complex with coagulation factor VIIa heavy chain, light chain and Ca+2 ion</scene> (PDB code [[1j9c]]).
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</StructureSection>
==3D structures of tissue factor==
==3D structures of tissue factor==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1a21]] – rTF extracellular domain – rabbit<br />
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*Tissue factor
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[[2hft]], [[1boy]], [[1tfh]] – hTF extracellular domain – human<br />
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===Tissue factor binary complex===
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**[[2hft]], [[1boy]], [[1tfh]] – hTF extracellular domain – human<br />
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**[[1a21]] – rTF extracellular domain – rabbit<br />
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[[1dan]], [[1j9c]], [[1w0y]] – hTF extracellular domain + factor VIIA<br />
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*Tissue factor binary complex
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[[1o5d]] – hTF extracellular domain (mutant) + factor VIIA<br />
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[[1ahw]], [[1jps]], [[1uj3]] – hTF extracellular domain + antibody<br />
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===Tissue factor ternary complex with coagulation factor VIIa and inhibitor===
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**[[1dan]], [[1j9c]], [[1w0y]], [[4ylq]], [[4z6a]], [[4zma]], [[6r2w]] – hTF extracellular domain + factor VIIA<br />
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**[[1o5d]] – hTF extracellular domain (mutant) + factor VIIA<br />
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**[[1ahw]], [[1jps]], [[1uj3]], [[4m7l]], [[5w06]] – hTF extracellular domain + antibody<br />
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[[1fak]] – hTF extracellular domain + factor VIIA + BPTI<br />
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*Tissue factor ternary complex with coagulation factor VIIa and inhibitor
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[[1z6j]], [[1w2k]], [[2b7d]], [[2f9b]], [[2flb]], [[2a2q]], [[2aer]], [[2fir]], [[2aei]], [[2c4f]], [[2flr]], [[2ec9]], [[2zp0]], [[2zzu]], [[3th2]], [[4ibl]] – hTF extracellular domain + factor VIIA + inhibitor<br />
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[[1wqv]], [[1wss]], [[1wtg]], [[1wun]], [[1wv7]], [[2b8o]], [[2puq]], [[3ela]], [[2zwl]], [[3th3]], [[3th4]] – hTF extracellular domain + factor VIIA + peptide mimetic inhibitor<br />
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**[[1fak]] – hTF extracellular domain + factor VIIA + BPTI<br />
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**[[1z6j]], [[1w2k]], [[2b7d]], [[2f9b]], [[2flb]], [[2a2q]], [[2aer]], [[2fir]], [[2aei]], [[2c4f]], [[2flr]], [[2ec9]], [[2zp0]], [[2zzu]], [[3th2]], [[4ibl]] – hTF extracellular domain + factor VIIA + inhibitor<br />
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**[[1wqv]], [[1wss]], [[1wtg]], [[1wun]], [[1wv7]], [[2b8o]], [[2puq]], [[3ela]], [[2zwl]], [[3th3]], [[3th4]] – hTF extracellular domain + factor VIIA + peptide mimetic inhibitor<br />
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}}
== References ==
== References ==

Current revision

Structure of human tissue factor (green) complex with coagulation factor VIIa heavy chain (magenta) and light chain (deep sky blue) and Ca+2 ion (green) (PDB code 1j9c).

Drag the structure with the mouse to rotate

3D structures of tissue factor

Updated on 26-February-2020

References

  1. ↑ Chen VM, Hogg PJ. Encryption and decryption of tissue factor. J Thromb Haemost. 2013 Jun;11 Suppl 1:277-84. doi: 10.1111/jth.12228. PMID:23809131 doi:http://dx.doi.org/10.1111/jth.12228
  2. ↑ Poon RT, Lau CP, Ho JW, Yu WC, Fan ST, Wong J. Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma. Clin Cancer Res. 2003 Nov 1;9(14):5339-45. PMID:14614019
  3. ↑ Pawlinski R, Tencati M, Holscher T, Pedersen B, Voet T, Tilley RE, Marynen P, Mackman N. Role of cardiac myocyte tissue factor in heart hemostasis. J Thromb Haemost. 2007 Aug;5(8):1693-700. PMID:17663739 doi:http://dx.doi.org/10.1111/j.1538-7836.2007.02649.x

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