Tissue factor

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<StructureSection load='1j9c' size='340' side='right' caption='Structure of human tissue factor (dark green) complex with coagulation factor VIIa heavy chain (red) and light chain (aqua) and Ca+2 ion (green) (PDB code [[2aer]]).' scene=''>
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<StructureSection load='' size='350' side='right' caption='Structure of human tissue factor (green) complex with coagulation factor VIIa heavy chain (magenta) and light chain (deep sky blue) and Ca+2 ion (green) (PDB code [[1j9c]]).' scene='59/595166/Cv/1'>
== Function ==
== Function ==
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== Relevance ==
== Relevance ==
TF expression by cardiac myocytes is important to maintain heart hemostasis under normal and pathologic conditions<ref>PMID:17663739</ref>.
TF expression by cardiac myocytes is important to maintain heart hemostasis under normal and pathologic conditions<ref>PMID:17663739</ref>.
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*<scene name='59/595166/Cv/3'>Human tissue factor complex with coagulation factor VIIa heavy chain, light chain and Ca+2 ion</scene> (PDB code [[1j9c]]).
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== Structural highlights ==
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</StructureSection>
</StructureSection>
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*Tissue factor
*Tissue factor
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**[[2hft]], [[1boy]], [[1tfh]] – hTF extracellular domain – human<br />
**[[1a21]] – rTF extracellular domain – rabbit<br />
**[[1a21]] – rTF extracellular domain – rabbit<br />
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**[[2hft]], [[1boy]], [[1tfh]] – hTF extracellular domain – human<br />
 
*Tissue factor binary complex
*Tissue factor binary complex
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**[[1dan]], [[1j9c]], [[1w0y]] – hTF extracellular domain + factor VIIA<br />
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**[[1dan]], [[1j9c]], [[1w0y]], [[4ylq]], [[4z6a]], [[4zma]], [[6r2w]] – hTF extracellular domain + factor VIIA<br />
**[[1o5d]] – hTF extracellular domain (mutant) + factor VIIA<br />
**[[1o5d]] – hTF extracellular domain (mutant) + factor VIIA<br />
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**[[1ahw]], [[1jps]], [[1uj3]], [[4m7l]] – hTF extracellular domain + antibody<br />
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**[[1ahw]], [[1jps]], [[1uj3]], [[4m7l]], [[5w06]] – hTF extracellular domain + antibody<br />
*Tissue factor ternary complex with coagulation factor VIIa and inhibitor
*Tissue factor ternary complex with coagulation factor VIIa and inhibitor

Current revision

Structure of human tissue factor (green) complex with coagulation factor VIIa heavy chain (magenta) and light chain (deep sky blue) and Ca+2 ion (green) (PDB code 1j9c).

Drag the structure with the mouse to rotate

3D structures of tissue factor

Updated on 26-February-2020

References

  1. ↑ Chen VM, Hogg PJ. Encryption and decryption of tissue factor. J Thromb Haemost. 2013 Jun;11 Suppl 1:277-84. doi: 10.1111/jth.12228. PMID:23809131 doi:http://dx.doi.org/10.1111/jth.12228
  2. ↑ Poon RT, Lau CP, Ho JW, Yu WC, Fan ST, Wong J. Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma. Clin Cancer Res. 2003 Nov 1;9(14):5339-45. PMID:14614019
  3. ↑ Pawlinski R, Tencati M, Holscher T, Pedersen B, Voet T, Tilley RE, Marynen P, Mackman N. Role of cardiac myocyte tissue factor in heart hemostasis. J Thromb Haemost. 2007 Aug;5(8):1693-700. PMID:17663739 doi:http://dx.doi.org/10.1111/j.1538-7836.2007.02649.x

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Michal Harel, Joel L. Sussman, Alexander Berchansky

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