Glycerate kinase

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[[Image:1to6.png|left|200px|thumb|Crystal Structure of glycerate kinase, [[1to6]]]]
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<StructureSection load='' size='350' side='right' caption='Glycerate kinase dimer complex with sulfate ions (PDB code [[1to6]]).' scene='Glycerate_kinase/Glycerate_kinase/1'>
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{{STRUCTURE_1to6| PDB=1to6 | SIZE=300| SCENE= |right|CAPTION=Glycerate kinase complex with SO4 ions, [[1to6]] }}
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== Function ==
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'''Glycerate kinase''' (GK) catalyzes the conversion of ATP + glycerate to ADP + 3-phospho-glycerate. GK participates in the metabolic pathways of serine/glycine/threonine, glycolipid and glyoxylate-dicarboxylate. GK is the last step in the pathway which starts with glucose and ends with 2-phosphoglycerate<ref>PMID:5325263</ref>.
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'''Glycerate kinase''' (GK) catalyzes the conversion of ATP + glycerate to ADP + 3-phospho-glycerate.
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== Disease ==
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Mutation in GK is the cause of inherited D-glyceric acidemia (D-glyceric aciduria)<ref>PMID:20949620</ref>.
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</StructureSection>
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== 3D Structures of glycerate kinase ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[1to6]] – GK – ''Neisseria meningitides''<br />
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[[2b8n]] – GK – ''Thermotoga maritima''<br />
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[[1x3l]] – GK – ''Pyrococcus horikoshii''<br />
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[[3cwc]] – GK – ''Salmonella enterica''<br />
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[[6ckg]] – GK – ''Cryptococcus neoformans''<br />
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{{TOC limit|limit=2}}
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== References ==
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<references/>
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[[Category:Topic Page]]
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== 3D Structures of glycerate kinase ==
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[[1to6]] – GK – ''Neisseria meningitides''
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Current revision

Glycerate kinase dimer complex with sulfate ions (PDB code 1to6).

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3D Structures of glycerate kinase

Updated on 03-March-2020

1to6 – GK – Neisseria meningitides
2b8n – GK – Thermotoga maritima
1x3l – GK – Pyrococcus horikoshii
3cwc – GK – Salmonella enterica
6ckg – GK – Cryptococcus neoformans

References

  1. ↑ Doughty CC, Hayashi JA, Guenther HL. Purification and properties of D-glycerate 3-kinase from Escherichia coli. J Biol Chem. 1966 Feb 10;241(3):568-72. PMID:5325263
  2. ↑ Sass JO, Fischer K, Wang R, Christensen E, Scholl-Burgi S, Chang R, Kapelari K, Walter M. D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase (GLYCTK). Hum Mutat. 2010 Dec;31(12):1280-5. doi: 10.1002/humu.21375. Epub 2010 Nov 9. PMID:20949620 doi:http://dx.doi.org/10.1002/humu.21375

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Eran Hodis

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