6y1e
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human glutathione transferase P1-1 (hGSTP1-1) that was co-crystallised in the presence of indanyloxyacetic acid-94 (IAA-94)== | |
| - | + | <StructureSection load='6y1e' size='340' side='right'caption='[[6y1e]], [[Resolution|resolution]] 1.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6y1e]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Y1E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=O7Z:2-[[6,7-bis(chloranyl)-2-cyclopentyl-2-methyl-1-oxidanylidene-3~{H}-inden-5-yl]oxy]ethanoic+acid'>O7Z</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gss|2gss]]</td></tr> |
| - | [[Category: Dirr, H | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6y1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y1e OCA], [http://pdbe.org/6y1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y1e RCSB], [http://www.ebi.ac.uk/pdbsum/6y1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y1e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Glutathione transferase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dirr, H W]] | ||
[[Category: Pandian, R]] | [[Category: Pandian, R]] | ||
| + | [[Category: Sayed, Y]] | ||
[[Category: Thangaraj, V]] | [[Category: Thangaraj, V]] | ||
| - | [[Category: Sayed, Y]] | ||
[[Category: Worth, R]] | [[Category: Worth, R]] | ||
| + | [[Category: Chloride ion channel inhibitor]] | ||
| + | [[Category: Clic1]] | ||
| + | [[Category: Ea]] | ||
| + | [[Category: Ethacrynic acid]] | ||
| + | [[Category: Glutathione transferase p1-1]] | ||
| + | [[Category: Iaa-94]] | ||
| + | [[Category: Indanyloxyacetic acid-94]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:34, 11 March 2020
Crystal structure of human glutathione transferase P1-1 (hGSTP1-1) that was co-crystallised in the presence of indanyloxyacetic acid-94 (IAA-94)
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