Tyrosine kinase 3D structures
From Proteopedia
(Difference between revisions)
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**[[1zbj]] - hTK Fyn SH3 domain – NMR<br />> | **[[1zbj]] - hTK Fyn SH3 domain – NMR<br />> | ||
**[[1g83]] - hTK Fyn SH2+SH3 domains (mutant)<br /> | **[[1g83]] - hTK Fyn SH2+SH3 domains (mutant)<br /> | ||
| + | **[[6edf]] - hTK Fyn residues 1-77<br /> | ||
**[[3uf4]] – mTK Fyn SH3-SH2 domain – mouse<br /> | **[[3uf4]] – mTK Fyn SH3-SH2 domain – mouse<br /> | ||
**[[3uf4]] - mTK Fyn SH2+SH3 domains<br /> | **[[3uf4]] - mTK Fyn SH2+SH3 domains<br /> | ||
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**[[2kk1]] – hTK C terminal – NMR<BR /> | **[[2kk1]] – hTK C terminal – NMR<BR /> | ||
| - | *'''Anaplastic lymphoma kinase (Alk)''' | + | *'''Anaplastic lymphoma kinase (Alk)''' or '''Alk tyrosine kinae receptor''' |
| - | **[[4tt7]] - hTK kinase domain<br /> | + | **[[4tt7]], [[6cdt]] - hTK kinase domain<br /> |
**[[3l9p]], [[3lcs]], [[3lct]], [[2yhv]], [[2yjr]], [[2yjs]], [[4fnw]], [[4fnx]], [[4anl]] - hTK kinase domain (mutant)<br /> | **[[3l9p]], [[3lcs]], [[3lct]], [[2yhv]], [[2yjr]], [[2yjs]], [[4fnw]], [[4fnx]], [[4anl]] - hTK kinase domain (mutant)<br /> | ||
| - | **[[2xb7]], [[2xba]], [[3aox]], [[5imx]], [[5kz0]], [[4ccb]], [[4ccu]], [[4cli]], [[4cmo]], [[4cmt]], [[4cmu]], [[4cnh]], [[4ctb]], [[4ctc]], [[6mx8]] | + | **[[2xb7]], [[2xba]], [[3aox]], [[5imx]], [[5kz0]], [[4ccb]], [[4ccu]], [[4cli]], [[4cmo]], [[4cmt]], [[4cmu]], [[4cnh]], [[4ctb]], [[4ctc]], [[6mx8]], [[6edl]], [[6ebw]], [[6e0r]] - hTK kinase domain + inhibitor<br /> |
**[[4dce]], [[4fob]], [[4foc]], [[4fod]], [[4fny]], [[4fnz]], [[4joa]], [[4mkc]], [[4z55]], [[5iug]], [[5iuh]], [[5iui]], [[4cd0]], [[4clj]] - hTK kinase domain (mutant) + inhibitor<br /> | **[[4dce]], [[4fob]], [[4foc]], [[4fod]], [[4fny]], [[4fnz]], [[4joa]], [[4mkc]], [[4z55]], [[5iug]], [[5iuh]], [[5iui]], [[4cd0]], [[4clj]] - hTK kinase domain (mutant) + inhibitor<br /> | ||
**[[2xp2]], [[6mx8]], [[5fto]], [[5ftq]] - hTK kinase domain + cancer drug<br /> | **[[2xp2]], [[6mx8]], [[5fto]], [[5ftq]] - hTK kinase domain + cancer drug<br /> | ||
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*Src tyrosine kinase SH3 domain | *Src tyrosine kinase SH3 domain | ||
| + | **[[6c4s]] – hTK + choline kinase peptide<br /> | ||
**[[1jeg]] – mTK + protein-tyrosine phosphatase peptide <br /> | **[[1jeg]] – mTK + protein-tyrosine phosphatase peptide <br /> | ||
**[[1srl]], [[1srm]] - cTK – NMR<br /> | **[[1srl]], [[1srm]] - cTK – NMR<br /> | ||
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**[[1yo6]] - hTK <br /> | **[[1yo6]] - hTK <br /> | ||
**[[1yoj]] - hTK (mutant) <br /> | **[[1yoj]] - hTK (mutant) <br /> | ||
| - | **[[2bdf]], [[2bdj]] – hTK + inhibitor<br /> | + | **[[2bdf]], [[2bdj]], [[6e6e]], [[6ate]] – hTK + inhibitor<br /> |
**[[1yol]], [[1yom]] – hTK (mutant) + inhibitor<br /> | **[[1yol]], [[1yom]] – hTK (mutant) + inhibitor<br /> | ||
**[[1byg]] – hTK + staurosporine<br /> | **[[1byg]] – hTK + staurosporine<br /> | ||
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**[[1xbb]] - hSyk kinase domain + Gleevec<br /> | **[[1xbb]] - hSyk kinase domain + Gleevec<br /> | ||
**[[1xbc]] - hSyk kinase domain + staurosporine<br /> | **[[1xbc]] - hSyk kinase domain + staurosporine<br /> | ||
| - | **[[3emg]], [[3fqe]], [[3fqh]], [[3fqs]], [[3srv]], [[4dfl]], [[4dfn]], [[3vf8]], [[3vf9]], [[3tub]], [[3tuc]], [[3tud]], [[4f4p]], [[4fyn]], [[4fyo]], [[4fz6]], [[4fz7]], [[4gfg]], [[4i0r]], [[4i0s]], [[4i0t]], [[4puz]], [[4pv0]], [[4rx7]], [[4rx8]], [[4rx9]], [[5lma]], [[5lmb]], [[5ghv]], [[4wnm]], [[4xg3]], [[4xg4]], [[4xg6]], [[4xg7]], [[4xg8]], [[4xg9]], [[4rss]], [[4yjv]], [[5c26]], [[5c27]], [[4yjo]], [[4yjp]], [[4yjq]], [[4yjr]], [[4yjs]], [[4yjt]], [[4yju]], [[5tr6]], [[5tt7]], [[5tiu]], [[5t68]], [[5y5t]], [[5y5u]], [[4gfg]], [[6hm6]], [[6hm7]] - hSyk kinase domain + inhibitor<br /> | + | **[[3emg]], [[3fqe]], [[3fqh]], [[3fqs]], [[3srv]], [[4dfl]], [[4dfn]], [[3vf8]], [[3vf9]], [[3tub]], [[3tuc]], [[3tud]], [[4f4p]], [[4fyn]], [[4fyo]], [[4fz6]], [[4fz7]], [[4gfg]], [[4i0r]], [[4i0s]], [[4i0t]], [[4puz]], [[4pv0]], [[4rx7]], [[4rx8]], [[4rx9]], [[5lma]], [[5lmb]], [[5ghv]], [[4wnm]], [[4xg3]], [[4xg4]], [[4xg6]], [[4xg7]], [[4xg8]], [[4xg9]], [[4rss]], [[4yjv]], [[5c26]], [[5c27]], [[4yjo]], [[4yjp]], [[4yjq]], [[4yjr]], [[4yjs]], [[4yjt]], [[4yju]], [[5tr6]], [[5tt7]], [[5tiu]], [[5t68]], [[5y5t]], [[5y5u]], [[4gfg]], [[6hm6]], [[6hm7]], [[6vov]] - hSyk kinase domain + inhibitor<br /> |
**[[4px6]], [[5cxh]], [[5cxz]], [[5cy3]] - hSyk kinase domain (mutant) + inhibitor<br /> | **[[4px6]], [[5cxh]], [[5cxz]], [[5cy3]] - hSyk kinase domain (mutant) + inhibitor<br /> | ||
**[[1csy]], [[1csz]] - hSyk SH2 domain + phosphopeptide – NMR<BR /> | **[[1csy]], [[1csz]] - hSyk SH2 domain + phosphopeptide – NMR<BR /> | ||
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**[[4tzi]] - hTK Lyn SH2 domain <br /> | **[[4tzi]] - hTK Lyn SH2 domain <br /> | ||
| + | **[[6nmw]] - hTK Lyn SH3 domain <br /> | ||
**[[1w1f]] - hTK Lyn SH3 domain – NMR<br /> | **[[1w1f]] - hTK Lyn SH3 domain – NMR<br /> | ||
**[[1wa7]] - hTK Lyn SH3 domain + peptide – NMR<br /> | **[[1wa7]] - hTK Lyn SH3 domain + peptide – NMR<br /> | ||
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**[[4uxl]] - hTK Ros kinase domain + inhibitor<br /> | **[[4uxl]] - hTK Ros kinase domain + inhibitor<br /> | ||
| - | *'''Tyk2 tyrosine kinase''' (Domains: SH2+FERM 23-540; pseudokinase 541-880; kinase 880-1170) | + | *'''Non-receptor Tyk2 tyrosine kinase''' (Domains: SH2+FERM 23-540; pseudokinase 541-880; kinase 880-1170) |
| - | **[[5f20]], [[5f1z]] - hTK Tyk2 kinase domain + inhibitor<br /> | + | **[[5f20]], [[5f1z]], [[6ova]] - hTK Tyk2 kinase domain + inhibitor<br /> |
**[[3lxn]], [[3lxp]], [[3nyx]], [[3nz0]], [[4e1z]], [[4e20]], [[4gfo]], [[4gih]], [[4gii]], [[4gj2]], [[4gj3]], [[4py1]], [[5wal]], [[5wev]], [[6dbk]], [[6dbm]] - hTK Tyk2 kinase domain (mutant) + inhibitor<br /> | **[[3lxn]], [[3lxp]], [[3nyx]], [[3nz0]], [[4e1z]], [[4e20]], [[4gfo]], [[4gih]], [[4gii]], [[4gj2]], [[4gj3]], [[4py1]], [[5wal]], [[5wev]], [[6dbk]], [[6dbm]] - hTK Tyk2 kinase domain (mutant) + inhibitor<br /> | ||
**[[6aam]] - hTK Tyk2 kinase domain (mutant) + drug<br /> | **[[6aam]] - hTK Tyk2 kinase domain (mutant) + drug<br /> | ||
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**[[4oli]] - hTK Tyk2 pseudokinase + kinase domains <br /> | **[[4oli]] - hTK Tyk2 pseudokinase + kinase domains <br /> | ||
**[[3zon]], [[5c01]], [[5c03]] - hTK Tyk2 pseudokinase domain <br /> | **[[3zon]], [[5c01]], [[5c03]] - hTK Tyk2 pseudokinase domain <br /> | ||
| - | **[[4wov]], [[5tkd]] - hTK Tyk2 pseudokinase domain + inhibitor<br /> | + | **[[4wov]], [[5tkd]], [[6nzr]], [[6nzq]], [[6nzp]], [[6nzh]], [[6nzf]], [[6nze]], [[6nsl]] - hTK Tyk2 pseudokinase domain + inhibitor<br /> |
**[[4po6]] - hTK Tyk2 SH2+FERM domains + IFNAR1 peptide<br /> | **[[4po6]] - hTK Tyk2 SH2+FERM domains + IFNAR1 peptide<br /> | ||
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**[[1b55]] - hTK Btk PH domain + inositol-tetrakisphosphate<br /> | **[[1b55]] - hTK Btk PH domain + inositol-tetrakisphosphate<br /> | ||
**[[1bwn]] - hTK Btk PH domain (mutant) + inositol-tetrakisphosphate<br /> | **[[1bwn]] - hTK Btk PH domain (mutant) + inositol-tetrakisphosphate<br /> | ||
| - | **[[3gen]], [[3ocs]], [[3pix]], [[3piy]], [[3piz]], [[3pj1]], [[3pj2]], [[3pj3]], [[4nwm]], [[4yhf]], [[5jrs]], [[5fbo]], [[5fbn]], [[4rx5]], [[5bpy]], [[5bq0]], [[5vgo]], [[5u9d]], [[5t18]], [[5p9m]], [[5p9l]], [[5p9m]], [[5p9l]], [[5p9f]], [[5p9g]], [[5p9h]], [[5p9i]], [[5p9j]], [[5p9k]], [[5vfi]], [[4z3v]], [[4zly]], [[4zlz]], [[5zz4]], [[6aua]], [[6aub]], [[5j87]], [[5xyz]], [[6bik]], [[6bke]], [[6bkh]], [[6bkw]], [[6bln]], [[6di0]], [[6di1]], [[6di3]], [[6di5]], [[6di9]], [[6e4f]], [[6e9p]], [[5kup]] - hTK Btk kinase domain + inhibitor<br /> | + | **[[3gen]], [[3ocs]], [[3pix]], [[3piy]], [[3piz]], [[3pj1]], [[3pj2]], [[3pj3]], [[4nwm]], [[4yhf]], [[5jrs]], [[5fbo]], [[5fbn]], [[4rx5]], [[5bpy]], [[5bq0]], [[5vgo]], [[5u9d]], [[5t18]], [[5p9m]], [[5p9l]], [[5p9m]], [[5p9l]], [[5p9f]], [[5p9g]], [[5p9h]], [[5p9i]], [[5p9j]], [[5p9k]], [[5vfi]], [[4z3v]], [[4zly]], [[4zlz]], [[5zz4]], [[6aua]], [[6aub]], [[5j87]], [[5xyz]], [[6bik]], [[6bke]], [[6bkh]], [[6bkw]], [[6bln]], [[6di0]], [[6di1]], [[6di3]], [[6di5]], [[6di9]], [[6e4f]], [[6e9p]], [[5kup]], [[6tfp]], [[6s90]], [[6o8i]], [[6nzm]], [[6nfi]], [[6nfh]], [[6n9p]] - hTK Btk kinase domain + inhibitor<br /> |
| - | **[[3k54]], [[3t9t]], [[4ot5]], [[4ot6]], [[4otq]], [[4otr]], [[4otf]], [[4rfy]], [[4rfz]], [[4rg0]], [[6ep9]] - hTK Btk kinase domain (mutant) + inhibitor<br /> | + | **[[3k54]], [[3t9t]], [[4ot5]], [[4ot6]], [[4otq]], [[4otr]], [[4otf]], [[4rfy]], [[4rfz]], [[4rg0]], [[6ep9]], [[6hrt]], [[6hrp]] - hTK Btk kinase domain (mutant) + inhibitor<br /> |
**[[5vgo]] - hTK Btk kinase domain + cancer drug<br /> | **[[5vgo]] - hTK Btk kinase domain + cancer drug<br /> | ||
**[[3oct]] - hTK Btk kinase domain (mutant) + cancer drug<br /> | **[[3oct]] - hTK Btk kinase domain (mutant) + cancer drug<br /> | ||
| + | **[[6omu]] - hTK Btk kinase domain + MS drug<br /> | ||
| + | **[[6j6m]] - hTK Btk kinase domain + MCL drug<br /> | ||
**[[4y94]] - bTK Btk kinase domain + inhibitor<br /> | **[[4y94]] - bTK Btk kinase domain + inhibitor<br /> | ||
| + | **[[6mny]] - mTK Btk kinase domain + inhibitor<br /> | ||
*'''c-FMS tyrosine kinase or macrophage colony-stimulating factor 1 receptor''' see [[Colony-stimulating factor receptor]] | *'''c-FMS tyrosine kinase or macrophage colony-stimulating factor 1 receptor''' see [[Colony-stimulating factor receptor]] | ||
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**[[1fvr]] - hTK Tie2 kinase domain <br /> | **[[1fvr]] - hTK Tie2 kinase domain <br /> | ||
| - | *'''Ret tyrosine kinase''' | + | *'''Ret tyrosine kinase''' or '''proto-oncogene tyrosine protein kinase receptor Re'''t |
| - | **[[5amn]] - hTK Ret kinase domain + inhibitor<br /> | + | **[[6nja]] - hTK Ret kinase domain<br /> |
| + | **[[6fek]] - hTK Ret kinase domain (mutant)<br /> | ||
| + | **[[5amn]], [[6vhg]] - hTK Ret kinase domain + inhibitor<br /> | ||
| + | **[[6i83]], [[6i82]] - hTK Ret kinase domain (mutant) + inhibitor<br /> | ||
| + | **[[6nec]], [[6ne7]] - hTK Ret kinase domain + cancer drug<br /> | ||
**[[4ux8]] - hTK Ret extracellular domain + GFR alpha 1<br /> | **[[4ux8]] - hTK Ret extracellular domain + GFR alpha 1<br /> | ||
Revision as of 10:42, 17 March 2020
3D structures of tyrosine kinase
Updated on 17-March-2020
