6m0j
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of 2019-nCoV spike receptor-binding domain bound with ACE2== | |
| - | + | <StructureSection load='6m0j' size='340' side='right'caption='[[6m0j]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6m0j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M0J FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Angiotensin-converting_enzyme_2 Angiotensin-converting enzyme 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.23 3.4.17.23] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m0j OCA], [http://pdbe.org/6m0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m0j RCSB], [http://www.ebi.ac.uk/pdbsum/6m0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m0j ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN]] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Angiotensin-converting enzyme 2]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Ge, J]] | [[Category: Ge, J]] | ||
[[Category: Lan, J]] | [[Category: Lan, J]] | ||
| + | [[Category: Shan, S]] | ||
[[Category: Wang, X]] | [[Category: Wang, X]] | ||
[[Category: Yu, J]] | [[Category: Yu, J]] | ||
| + | [[Category: Receptor binding]] | ||
| + | [[Category: Spike]] | ||
| + | [[Category: Viral protein-hydrolase complex]] | ||
Revision as of 09:42, 18 March 2020
Crystal structure of 2019-nCoV spike receptor-binding domain bound with ACE2
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