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5c2e
From Proteopedia
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==PDE10 complexed with6-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-2-[2-(2-pyridyl)ethoxy]pyrimidin-4-amine== | ==PDE10 complexed with6-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-2-[2-(2-pyridyl)ethoxy]pyrimidin-4-amine== | ||
| - | <StructureSection load='5c2e' size='340' side='right' caption='[[5c2e]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='5c2e' size='340' side='right'caption='[[5c2e]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5c2e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C2E FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5c2e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C2E FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4PX:3-(1-HYDROXY-2-METHYLPROPAN-2-YL)-5-PHENYL-3,5-DIHYDRO-1H-IMIDAZO[4,5-C][1,8]NAPHTHYRIDINE-2,4-DIONE'>4PX</scene>, <scene name='pdbligand=4Y1:6-CHLORO-N-[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHYL]-5-METHYL-2-[2-(PYRIDIN-2-YL)ETHOXY]PYRIMIDIN-4-AMINE'>4Y1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4PX:3-(1-HYDROXY-2-METHYLPROPAN-2-YL)-5-PHENYL-3,5-DIHYDRO-1H-IMIDAZO[4,5-C][1,8]NAPHTHYRIDINE-2,4-DIONE'>4PX</scene>, <scene name='pdbligand=4Y1:6-CHLORO-N-[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHYL]-5-METHYL-2-[2-(PYRIDIN-2-YL)ETHOXY]PYRIMIDIN-4-AMINE'>4Y1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5c1w|5c1w]], [[5c28|5c28]], [[5c29|5c29]], [[5c2a|5c2a]], [[5c2h|5c2h]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5c1w|5c1w]], [[5c28|5c28]], [[5c29|5c29]], [[5c2a|5c2a]], [[5c2h|5c2h]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c2e OCA], [http://pdbe.org/5c2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c2e RCSB], [http://www.ebi.ac.uk/pdbsum/5c2e PDBsum]</span></td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c2e OCA], [http://pdbe.org/5c2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c2e RCSB], [http://www.ebi.ac.uk/pdbsum/5c2e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c2e ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5c2e" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5c2e" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Yan, Y]] | [[Category: Yan, Y]] | ||
[[Category: Complex]] | [[Category: Complex]] | ||
Revision as of 11:09, 18 March 2020
PDE10 complexed with6-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-2-[2-(2-pyridyl)ethoxy]pyrimidin-4-amine
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