This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1aui

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1aui.jpg|left|200px]]
[[Image:1aui.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1aui |SIZE=350|CAPTION= <scene name='initialview01'>1aui</scene>, resolution 2.1&Aring;
+
The line below this paragraph, containing "STRUCTURE_1aui", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=CA1:Ca+Binding+Site'>CA1</scene>, <scene name='pdbsite=CA2:Ca+Binding+Site'>CA2</scene>, <scene name='pdbsite=CA3:Ca+Binding+Site'>CA3</scene>, <scene name='pdbsite=CA4:Ca+Binding+Site'>CA4</scene>, <scene name='pdbsite=FEB:Fe+Binding+Site'>FEB</scene> and <scene name='pdbsite=ZNB:Zn+Binding+Site'>ZNB</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1aui| PDB=1aui | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aui OCA], [http://www.ebi.ac.uk/pdbsum/1aui PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aui RCSB]</span>
+
-
}}
+
'''HUMAN CALCINEURIN HETERODIMER'''
'''HUMAN CALCINEURIN HETERODIMER'''
Line 33: Line 30:
[[Category: Tempczyk, A.]]
[[Category: Tempczyk, A.]]
[[Category: Villafranca, J E.]]
[[Category: Villafranca, J E.]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: immunosuppression]]
+
[[Category: Immunosuppression]]
-
[[Category: phosphatase]]
+
[[Category: Phosphatase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:42:18 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:47:50 2008''
+

Revision as of 07:42, 2 May 2008

Image:1aui.jpg

Template:STRUCTURE 1aui

HUMAN CALCINEURIN HETERODIMER


Overview

Calcineurin (CaN) is a calcium- and calmodulin-dependent protein serine/threonine phosphate which is critical for several important cellular processes, including T-cell activation. CaN is the target of the immunosuppressive drugs cyclosporin A and FK506, which inhibit CaN after forming complexes with cytoplasmic binding proteins (cyclophilin and FKBP12, respectively). We report here the crystal structures of full-length human CaN at 2.1 A resolution and of the complex of human CaN with FKBP12-FK506 at 3.5 A resolution. In the native CaN structure, an auto-inhibitory element binds at the Zn/Fe-containing active site. The metal-site geometry and active-site water structure suggest a catalytic mechanism involving nucleophilic attack on the substrate phosphate by a metal-activated water molecule. In the FKBP12-FK506-CaN complex, the auto-inhibitory element is displaced from the active site. The site of binding of FKBP12-FK506 appears to be shared by other non-competitive inhibitors of calcineurin, including a natural anchoring protein.

About this Structure

1AUI is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex., Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW, et al., Nature. 1995 Dec 7;378(6557):641-4. PMID:8524402 Page seeded by OCA on Fri May 2 10:42:18 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1aui"
Personal tools