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6jkb
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of metallo-beta-lactamse, NDM-1, in complex with hydrolyzed ampicillin== | |
| - | + | <StructureSection load='6jkb' size='340' side='right'caption='[[6jkb]], [[Resolution|resolution]] 2.44Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6jkb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JKB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=ZZ7:(2R,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ZZ7</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jkb OCA], [http://pdbe.org/6jkb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jkb RCSB], [http://www.ebi.ac.uk/pdbsum/6jkb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jkb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Beta-lactamase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fudo, S]] | ||
| + | [[Category: Hayashi, U]] | ||
| + | [[Category: Hoshino, T]] | ||
[[Category: Kamo, T]] | [[Category: Kamo, T]] | ||
[[Category: Kondo, S]] | [[Category: Kondo, S]] | ||
| + | [[Category: Kuroda, K]] | ||
[[Category: Nukaga, M]] | [[Category: Nukaga, M]] | ||
| - | [[Category: | + | [[Category: Antibiotic]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | + | ||
| - | + | ||
Revision as of 10:02, 27 March 2020
Crystal structure of metallo-beta-lactamse, NDM-1, in complex with hydrolyzed ampicillin
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Categories: Beta-lactamase | Large Structures | Fudo, S | Hayashi, U | Hoshino, T | Kamo, T | Kondo, S | Kuroda, K | Nukaga, M | Antibiotic | Hydrolase
