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6od0
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human CIB1 in complex with peptide inhibitor UNC10245092== | |
| - | + | <StructureSection load='6od0' size='340' side='right'caption='[[6od0]], [[Resolution|resolution]] 2.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6od0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OD0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OD0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6od0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6od0 OCA], [http://pdbe.org/6od0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6od0 RCSB], [http://www.ebi.ac.uk/pdbsum/6od0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6od0 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CIB1_HUMAN CIB1_HUMAN]] May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.<ref>PMID:12714504</ref> <ref>PMID:12881299</ref> <ref>PMID:15685448</ref> <ref>PMID:18627437</ref> <ref>PMID:19805025</ref> <ref>PMID:21264284</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Godoy, A S]] | ||
| + | [[Category: Pearce, K]] | ||
| + | [[Category: Puhl, A C]] | ||
| + | [[Category: Cancer]] | ||
| + | [[Category: Cib1]] | ||
| + | [[Category: Metal binding protein]] | ||
Revision as of 10:10, 27 March 2020
Structure of human CIB1 in complex with peptide inhibitor UNC10245092
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