1awc

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[[Image:1awc.gif|left|200px]]
[[Image:1awc.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1awc |SIZE=350|CAPTION= <scene name='initialview01'>1awc</scene>, resolution 2.150&Aring;
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The line below this paragraph, containing "STRUCTURE_1awc", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BRU:5-BROMO-2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=CBR:5-BROMO-2&#39;-DEOXY-CYTIDINE-5&#39;-MONOPHOSPHATE'>CBR</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= GABP ALPHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), GABP BETA 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_1awc| PDB=1awc | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1awc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1awc OCA], [http://www.ebi.ac.uk/pdbsum/1awc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1awc RCSB]</span>
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}}
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'''MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA'''
'''MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA'''
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[[Category: Batchelor, A H.]]
[[Category: Batchelor, A H.]]
[[Category: Wolberger, C.]]
[[Category: Wolberger, C.]]
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[[Category: ankyrin repeat]]
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[[Category: Ankyrin repeat]]
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[[Category: complex (transcription regulation/dna)]]
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[[Category: Dna-binding]]
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[[Category: dna-binding]]
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[[Category: Ets domain]]
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[[Category: ets domain]]
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[[Category: Nuclear protein]]
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[[Category: nuclear protein]]
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[[Category: Transcription factor]]
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[[Category: transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:46:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:48:47 2008''
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Revision as of 07:46, 2 May 2008

Image:1awc.gif

Template:STRUCTURE 1awc

MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA


Overview

GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The alpha subunit contains a DNA-binding domain that is a member of the ETS family, whereas the beta subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2. 15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPalpha ETS domain binds to its core GGA DNA-recognition motif.

About this Structure

1AWC is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA., Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C, Science. 1998 Feb 13;279(5353):1037-41. PMID:9461436 Page seeded by OCA on Fri May 2 10:46:29 2008

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OCA

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