5czm

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==Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470==
==Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470==
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<StructureSection load='5czm' size='340' side='right' caption='[[5czm]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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<StructureSection load='5czm' size='340' side='right'caption='[[5czm]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5czm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CZM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5czm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CZM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=R47:N-[(2S)-3-[(S)-(4-BROMOPHENYL)(HYDROXY)PHOSPHORYL]-2-{[3-(3-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}PROPANOYL]-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMINE'>R47</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=R47:N-[(2S)-3-[(S)-(4-BROMOPHENYL)(HYDROXY)PHOSPHORYL]-2-{[3-(3-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}PROPANOYL]-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMINE'>R47</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MMP12, HME ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5czm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5czm OCA], [http://pdbe.org/5czm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5czm RCSB], [http://www.ebi.ac.uk/pdbsum/5czm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5czm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5czm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5czm OCA], [http://pdbe.org/5czm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5czm RCSB], [http://www.ebi.ac.uk/pdbsum/5czm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5czm ProSAT]</span></td></tr>
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</div>
</div>
<div class="pdbe-citations 5czm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5czm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Macrophage elastase]]
[[Category: Macrophage elastase]]
[[Category: Devel, L]]
[[Category: Devel, L]]
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[[Category: Rouanet-Mehouas, C]]
[[Category: Rouanet-Mehouas, C]]
[[Category: Stura, E A]]
[[Category: Stura, E A]]
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[[Category: Human]]
 
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Macrophage]]
[[Category: Macrophage]]

Revision as of 10:30, 1 April 2020

Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470

PDB ID 5czm

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