1axc

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[[Image:1axc.gif|left|200px]]
[[Image:1axc.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1axc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1axc OCA], [http://www.ebi.ac.uk/pdbsum/1axc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1axc RCSB]</span>
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'''HUMAN PCNA'''
'''HUMAN PCNA'''
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[[Category: Gulbis, J M.]]
[[Category: Gulbis, J M.]]
[[Category: Kuriyan, J.]]
[[Category: Kuriyan, J.]]
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[[Category: cip1]]
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[[Category: Cip1]]
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[[Category: complex (dna-binding protein/dna)]]
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[[Category: Dna]]
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[[Category: dna]]
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[[Category: Oncogene]]
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[[Category: oncogene]]
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[[Category: Processivity]]
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[[Category: processivity]]
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[[Category: Replication]]
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[[Category: replication]]
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[[Category: Waf1]]
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[[Category: waf1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:48:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:49:20 2008''
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Revision as of 07:48, 2 May 2008

Image:1axc.gif

Template:STRUCTURE 1axc

HUMAN PCNA


Overview

The crystal structure of the human DNA polymerase delta processivity factor PCNA (proliferating cell nuclear antigen) complexed with a 22 residue peptide derived from the C-terminus of the cell-cycle checkpoint protein p21(WAF1/CIP1) has been determined at 2.6 angstrom resolution. p21 binds to PCNA in a 1:1 stoichiometry with an extensive array of interactions that include the formation of a beta sheet with the interdomain connector loop of PCNA. An intact trimeric ring is maintained in the structure of the p21-PCNA complex, with a central hole available for DNA interaction. The ability of p21 to inhibit the action of PCNA is therefore likely to be due to its masking of elements on PCNA that are required for the binding of other components of the polymerase assembly.

About this Structure

1AXC is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA., Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J, Cell. 1996 Oct 18;87(2):297-306. PMID:8861913 Page seeded by OCA on Fri May 2 10:48:27 2008

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