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6vpr
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the C-terminal domain of DENR== | |
| - | + | <StructureSection load='6vpr' size='340' side='right'caption='[[6vpr]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6vpr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VPR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VPR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6vpq|6vpq]]</td></tr> |
| - | [[Category: Lomakin, I | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vpr OCA], [http://pdbe.org/6vpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vpr RCSB], [http://www.ebi.ac.uk/pdbsum/6vpr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vpr ProSAT]</span></td></tr> |
| - | [[Category: Steitz, T | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DENR_HUMAN DENR_HUMAN]] May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.<ref>PMID:16982740</ref> <ref>PMID:17878526</ref> <ref>PMID:20713520</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lomakin, I B]] | ||
| + | [[Category: Steitz, T A]] | ||
| + | [[Category: Protein synthesis regulation]] | ||
| + | [[Category: Translation]] | ||
| + | [[Category: Translation initiation]] | ||
| + | [[Category: Translation recycling]] | ||
| + | [[Category: Translation reinitiation]] | ||
Revision as of 06:59, 8 April 2020
Crystal structure of the C-terminal domain of DENR
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